Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants.

Peroxides localized at oxidative stress sites trigger prodrug release for treating chronic pain in mice.

Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.

ReChb is a Cas12a nuclease with expanded target access and substrate recognition.

DRAGEN rapidly identifies diverse types of genetic variants.

Protein–protein interactomes incorporating structural data predict the functional consequences of disease mutations.

Europe’s first field trial of gene-edited vines began in northern Italy on 30 September 2024. Developed by EdiVite, a spinoff from the University of Verona, these Chardonnay vines have undergone gene inactivation to enable them to better defend themselves against downy mildew, a major fungal disease. The trial is being conducted on university land, with plans to expand to another site in the Veneto region. Researchers aim to gather initial data by 2025, with the potential for experimental winemaking in 2026.

A strategic move by lawyers acting for Doudna and Charpentier is the latest twist in the battleground for CRISPR–Cas9 technology.

The Nobel Prize in medicine was awarded for the discovery of miRNA, but miRNA therapeutics have a long way to go before they outcompete other therapies.

Precision genetic methods are enabling more efficient, environmentally friendly pest control methods for agricultural use as well as stopping the spread of disease.