Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal. (Q42807632)

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scientific article published on 28 November 2005

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English	Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.	scientific article published on 28 November 2005

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9 January 2020

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal (English)

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9 January 2020

Mark F van Delft

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9 January 2020

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Lisa M Ellerby

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9 January 2020

Albert R. La Spada

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Albert R La Spada

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9 January 2020

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Jillian Taylor

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9 January 2020

Sara K Grote

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9 January 2020

Jianrun Xia

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9 January 2020

Joanna Graczyk

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9 January 2020

Ray Truant

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9 January 2020

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28 November 2005

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9 January 2020

Journal of Biological Chemistry

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9 January 2020

281

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9 January 2020

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9 January 2020

2730-2739

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9 January 2020

Insights into the molecular basis of polyglutamine neurodegeneration from studies of a spinocerebellar ataxia type 7 mouse model

1 reference

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Spinocerebellar ataxia 7 (SCA7).

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SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

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Fourteen and counting: unraveling trinucleotide repeat diseases

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Autosomal dominant cerebellar ataxia with pigmentary macular dystrophy. A clinical and genetic study of eight families

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Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

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Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

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Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization

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Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

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21 January 2018

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

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SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

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Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7

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21 January 2018

Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity

1 reference

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21 January 2018

Identification and localization of ataxin-7 in brain and retina of a patient with cerebellar ataxia type II using anti-peptide antibody.

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21 January 2018

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

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CRM1 is an export receptor for leucine-rich nuclear export signals

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21 January 2018

Quantitative imaging of protein interactions in the cell nucleus

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Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro

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Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3.

1 reference

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Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

1 reference

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21 January 2018

NESbase version 1.0: a database of nuclear export signals

1 reference

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21 January 2018

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha

1 reference

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21 January 2018

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

1 reference

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21 January 2018

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo

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21 January 2018

Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction

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21 January 2018

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

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21 January 2018

Nuclear transport and transcriptional regulation

1 reference

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21 January 2018

Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation

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Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor

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21 January 2018

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

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RNA association and nucleocytoplasmic shuttling by ataxin-1

1 reference

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21 January 2018

Huntingtin contains a highly conserved nuclear export signal

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An integrative approach to gain insights into the cellular function of human ataxin-2

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A composite nuclear export signal in the TBP-associated factor TAFII105.

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Spinobulbar muscular atrophy: polyglutamine-expanded androgen receptor is proteolytically resistant in vitro and processed abnormally in transfected cells.

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Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.

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Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2.

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Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus

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Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex

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Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

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Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

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Conserved Phosphoprotein Interaction Motif Is Functionally Interchangeable between Ataxin-7 and Arrestins†

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Distribution of ataxin-7 in normal human brain and retina

1 reference

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10.1074/JBC.M506751200

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16314424%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16314424%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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