Janus kinase 1 (Q6155967)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

FERM superfamily, second domain

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

Band 4.1 domain, protein family

1 reference

FERM central domain, protein family

1 reference

FERM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

16 January 2019

1 reference

16 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

CCR5 chemokine receptor binding

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

protein binding

5 references

8 April 2019

Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

7 references

8 April 2019

8 April 2019

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

8 April 2019

Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

EXP

8 April 2019

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

EXP

8 April 2019

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

protein phosphatase binding

EXP

1 reference

8 April 2019

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

signaling receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

ubiquitin protein ligase binding

1 reference

8 April 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

non-membrane spanning protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

4 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

31 October 2017

non-membrane spanning protein tyrosine kinase activity

growth hormone receptor binding

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

cell component

cytoplasm

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

focal adhesion

1 reference

31 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

extrinsic component of cytoplasmic side of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

endomembrane system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

nucleus

1 reference

8 April 2019

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

focal adhesion

HDA

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

HDA

biological process

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

transmembrane receptor protein tyrosine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

interferon-gamma-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

response to antibiotic

1 reference

8 April 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

positive regulation of sprouting angiogenesis

IGI

1 reference

8 April 2019

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

regulation of type I interferon-mediated signaling pathway

IGI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

regulation of interferon-gamma-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

regulation of cell population proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

type I interferon signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-2-mediated signaling pathway

1 reference

31 October 2017

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

peptidyl-tyrosine autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

protein autophosphorylation

Ensembl genome database project

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

1 reference

31 October 2017

interleukin-12-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-7-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-15-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-9-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

regulation of molecular function

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

interleukin-21-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-6-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-27-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

interleukin-35-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458

1 reference

8 April 2019

physically interacts with

filgotinib

1 reference

ClinicalTrials.gov ID

1 reference

7792

17 August 2016

1 reference

7791

17 August 2016

1 reference

7793

17 August 2016

1 reference

5688

English

17 August 2016

filgotinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301607

momelotinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1078178

upadacitinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3622821

peficitinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137308

Gene Atlas image

PBB GE JAK1 201648 at fs.png
732 × 530; 11 KB

0 references

has part(s)

tyrosine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Band 4.1 domain

1 reference

FERM central domain

1 reference

FERM domain

1 reference

D08.811.913.696.620.682.725.124.100

Identifiers

MeSH descriptor ID

D053613

subject named as

Janus Kinase 1

0 references

MeSH tree code

D12.776.476.568.124.100

0 references

0 references

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 November 2018

1 reference

16 January 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023