Is type 2 diabetes an amyloidosis and does it really matter (to patients)? (Q62228830)

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scientific article published on 13 March 2010

Language	Label	Description	Also known as
English	Is type 2 diabetes an amyloidosis and does it really matter (to patients)?	scientific article published on 13 March 2010

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Is type 2 diabetes an amyloidosis and does it really matter (to patients)? (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

type 2 diabetes

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

J F Aitken

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

publication date

13 March 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

53

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1011-1016

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20229094%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Watching amyloid fibrils grow by time-lapse atomic force microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein misfolding inside cells: the case of huntingtin and Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide association studies provide new insights into type 2 diabetes aetiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyalinization of the islets of Langerhans in nondiabetic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative studies on amyloid in the islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic Fibrillar Assembly of Human Amylin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas-associated death receptor signaling evoked by human amylin in islet beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid deposits: protection against toxic protein species?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute application of human amylin, unlike beta-amyloid peptides, kills undifferentiated PC12 cells by apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein conformational misfolding and amyloid formation: characteristics of a new class of disorders that include Alzheimer's and Prion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyalinization of the islet of Langerhans in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural history of beta-cell dysfunction in NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuries

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic β-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20229094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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