A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation (Q24655468)

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Language	Label	Description	Also known as
English	A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation	scientific article

Statements

instance of

scholarly article

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title

A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation (English)

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main subject

cell biology

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author name string

Steven Pennock

series ordinal

1

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Zhixiang Wang

series ordinal

2

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language of work or name

English

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publication date

May 2008

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published in

Molecular and Cellular Biology

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volume

28

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issue

9

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page(s)

3020-37

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cites work

Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment

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Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

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7 April 2017

CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases

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7 April 2017

cbl-3: a new mammalian cbl family protein

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7 April 2017

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene

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7 April 2017

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

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PubMed Central

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7 April 2017

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

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28 September 2017

Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes

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7 April 2017

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

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PubMed Central

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7 April 2017

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

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PubMed Central

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7 April 2017

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

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PubMed Central

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7 April 2017

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

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7 April 2017

cbl-b inhibits epidermal growth factor receptor signaling

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PubMed Central

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7 April 2017

Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

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PubMed Central

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7 April 2017

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

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PubMed Central

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7 April 2017

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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PubMed Central

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7 April 2017

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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PubMed Central

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7 April 2017

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

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PubMed Central

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7 April 2017

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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PubMed Central

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7 April 2017

Growth factor signaling by receptor tyrosine kinases

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PubMed Central

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7 April 2017

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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7 April 2017

Identification of EGF receptor C-terminal sequences 1005-1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosis

1 reference

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PubMed Central

reference URL

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28 September 2017

Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth

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PubMed Central

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28 September 2017

Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Distinct monoubiquitin signals in receptor endocytosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Grb2 regulates internalization of EGF receptors through clathrin-coated pits

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Cbl: many adaptations to regulate protein tyrosine kinases

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Neu and its ligands: from an oncogene to neural factors

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

Receptors for epidermal growth factor and other polypeptide mitogens

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 September 2017

c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

retrieved

28 September 2017

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

retrieved

28 November 2018

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

retrieved

28 November 2018

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

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28 November 2018

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

retrieved

28 November 2018

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2293090

retrieved

28 November 2018

The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Raf gets it together

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18316398

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/MCB.01809-07

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PMC publication ID

2293090

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PubMed publication ID

18316398

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ResearchGate publication ID

5536641

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