bleomycin A2 (Q26841044): Difference between revisions

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Property / instance of
 
Property / instance of: chemical compound / rank
Normal rank
 
Property / instance of: chemical compound / reference
 

Revision as of 17:35, 16 August 2023

chemical compound
  • bleomycin A₂
  • bleogin
  • N1-[3-(Dimethylsulfonio)propyl]bleomycinamide
  • pingyangmycin A2
  • zhengguangmycin A2
Language Label Description Also known as
English
bleomycin A2
chemical compound
  • bleomycin A₂
  • bleogin
  • N1-[3-(Dimethylsulfonio)propyl]bleomycinamide
  • pingyangmycin A2
  • zhengguangmycin A2

Statements

subclass of
thiazole alkaloid
0 references
bleomycins
0 references
mass
1,414.518981±0 dalton
1 reference
stated in
PubChem
PubChem CID
5460769
language of work or name
English
title
bleomycin a2 (English)
retrieved
21 September 2016
chemical formula
C₅₅H₈₄N₁₇O₂₁S₃+
1 reference
stated in
PubChem
PubChem CID
5460769
language of work or name
English
title
bleomycin a2 (English)
retrieved
21 September 2016
canonical SMILES
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
1 reference
stated in
PubChem
PubChem CID
5460769
language of work or name
English
title
bleomycin a2 (English)
retrieved
21 September 2016
isomeric SMILES
CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
1 reference
stated in
PubChem
PubChem CID
5460769
language of work or name
English
title
bleomycin a2 (English)
retrieved
21 September 2016
found in taxon
Streptomyces verticillus
16 references
stated in
Bleomycin Biosynthesis inStreptomyces verticillusATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis
stated in
THE CHEMISTRY OF BLEOMYCIN. IX
stated in
Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003.
stated in
The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus
stated in
In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway
stated in
Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture
stated in
Gene organization in the bleomycin-resistance region of the producer organism Streptomyces verticillus
stated in
A mammalian vector carrying the bleomycin N-acetyltransferase gene from bleomycin-producing Streptomyces verticillus as a selective marker
stated in
Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin
stated in
Overproduction of the bleomycin-binding proteins from bleomycin-producing Streptomyces verticillus and a methicillin-resistant Staphylococcus aureus in Escherichia coli and their immunological characterisation.
stated in
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
stated in
Production of bleomycin N-acetyltransferase in Escherichia coli and Streptomyces verticillus
stated in
Mutation of the N-terminal proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin.
stated in
Negative regulation of bleomycins biosynthesis by ArsR/SmtB family repressor BlmR in Streptomyces verticillus
stated in
An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.
stated in
The 1.5 A crystal structure of a bleomycin resistance determinant from bleomycin-producing Streptomyces verticillus
different from
bleomycin
0 references

Identifiers

Reaxys registry number
4379083
0 references
Gmelin number
1667354
0 references
EC number
234-356-5
1 reference
stated in
ECHA Substance Infocard database
ECHA Substance Infocard ID
100.031.220
retrieved
27 December 2018
title
Bleomycinamide, N1-[3-(dimethylsulfonio)propyl]- (English)
quotation
CAS no.: 11116-31-7 (English)
ECHA Substance Infocard ID
100.031.220
1 reference
stated in
ECHA Substance Infocard database
ECHA Substance Infocard ID
100.031.220
retrieved
27 December 2018
title
Bleomycinamide, N1-[3-(dimethylsulfonio)propyl]- (English)
quotation
CAS no.: 11116-31-7 (English)
KNApSAcK ID
C00018738
0 references
UNII
13M89UEA7W
0 references
KEGG ID
C06854
0 references
 
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