Male-specific lethal 2 Dmel_CG3241 (Q29819643)

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Protein found in Drosophila melanogaster

• male-specific-lethal-2
• male specific lethal 2
• msl-2
• males specific lethal 2
• Male-Specific lethal 2
• killer of males
• male-specific-lethal 2
• CG3241-PA
• CG3241 gene product from transcript CG3241-RB
• male specific-lethal 2
• male specifc lethal
• msl-2-PA
• msl-2-PB
• CG3241-PB
• killer-of-males-A

edit

Language	Label	Description	Also known as
English	Male-specific lethal 2 Dmel_CG3241	Protein found in Drosophila melanogaster	male-specific-lethal-2 male specific lethal 2 msl-2 males specific lethal 2 Male-Specific lethal 2 killer of males male-specific-lethal 2 CG3241-PA CG3241 gene product from transcript CG3241-RB male specific-lethal 2 male specifc lethal msl-2-PA msl-2-PB CG3241-PB killer-of-males-A

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P50534

part of

Zinc finger, RING/FYVE/PHD-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

E3 ubiquitin-protein ligase MSL2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

E3 ubiquitin-protein ligase Msl2, zinc RING finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tesmin/TSO1-like CXC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

E3 ubiquitin-protein ligase Msl2, CXC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P50534

encoded by

msl-2

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P50534

molecular function

DNA binding

determination method or standard

IDA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

RNAs templating chromatin structure for dosage compensation in animals

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P50534

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

retrieved

8 April 2019

stated in

The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

chromatin binding

determination method or standard

IDA

3 references

retrieved

8 April 2019

stated in

The chromosomal high-affinity binding sites for the Drosophila dosage compensation complex.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

8 April 2019

stated in

Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

8 April 2019

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

transcription factor binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IPI

metal ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P50534

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

ubiquitin protein ligase activity

determination method or standard

IDA

IEA

3 references

retrieved

27 February 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50534&geneProductId=UniProtKB:P50534

determination method or standard

IEA

retrieved

27 February 2018

stated in

Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50534&geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

27 February 2018

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50534&geneProductId=UniProtKB:P50534

determination method or standard

IDA

transferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P50534

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

ubiquitin protein ligase activity

determination method or standard

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

retrieved

8 April 2019

stated in

Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

8 April 2019

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IBA

cell component

nuclear chromosome

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

X chromosome

determination method or standard

IDA

NAS

2 references

retrieved

8 April 2019

stated in

Multiple RNA-protein interactions in Drosophila dosage compensation

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

NAS

retrieved

8 April 2019

stated in

The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

nucleus

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P50534

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

chromosome

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P50534

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

X chromosome located dosage compensation complex, transcription activating

determination method or standard

NAS

TAS

2 references

retrieved

8 April 2019

stated in

Multiple RNA-protein interactions in Drosophila dosage compensation

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

TAS

retrieved

8 April 2019

stated in

Structure, function and evolution of sex-determining systems in Dipteran insects

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

NAS

dosage compensation complex

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Targeting determinants of dosage compensation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

MSL complex

determination method or standard

IDA

IEA

2 references

retrieved

27 February 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50534&geneProductId=UniProtKB:P50534

determination method or standard

IEA

retrieved

27 February 2018

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50534&geneProductId=UniProtKB:P50534

determination method or standard

IDA

MSL complex

determination method or standard

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IEA

retrieved

8 April 2019

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IBA

biological process

protein polyubiquitination

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

dosage compensation

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IMP

dosage compensation by hyperactivation of X chromosome

determination method or standard

NAS

2 references

retrieved

8 April 2019

stated in

Structure, function and evolution of sex-determining systems in Dipteran insects

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

NAS

retrieved

8 April 2019

stated in

Multiple RNA-protein interactions in Drosophila dosage compensation

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

NAS

dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

RNAs templating chromatin structure for dosage compensation in animals

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

TAS

protein ubiquitination

determination method or standard

IDA

1 reference

retrieved

27 February 2018

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P50534&geneProductId=UniProtKB:P50534

determination method or standard

IDA

histone H4-K16 acetylation

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IBA

protein autoubiquitination

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

protein ubiquitination

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50534

determination method or standard

IBA

has part(s)

E3 ubiquitin-protein ligase Msl2, zinc RING finger

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

Tesmin/TSO1-like CXC domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

Zinc finger, RING-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

Zinc finger, RING-type, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

E3 ubiquitin-protein ligase Msl2, CXC domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P50534

Identifiers

RefSeq protein ID

NP_523467

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

33565

NP_722907

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

33565

UniProt protein ID

P50534

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

P50534

Ensembl protein ID

FBpp0077260

1 reference

stated in

ensembl Release 106

Ensembl protein ID

FBpp0077260

FBpp0077259

1 reference

stated in

ensembl Release 106

Ensembl protein ID

FBpp0077259

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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