A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation. (Q33869231)

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Language	Label	Description	Also known as
English	A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.	scientific article

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8 December 2019

A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation (English)

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8 December 2019

1

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8 December 2019

author name string

J F Bromberg

2

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8 December 2019

J E Darnell

3

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8 December 2019

H Hanafusa

4

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8 December 2019

language of work or name

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1 February 1999

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8 December 2019

Molecular and Cellular Biology

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8 December 2019

19

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8 December 2019

2

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8 December 2019

1401-1409

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8 December 2019

Determinants for transformation induced by the Axl receptor tyrosine kinase

1 reference

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28 July 2018

Stat3 activation is required for cellular transformation by v-src

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Activation of STAT3 by the c-Fes protein-tyrosine kinase

1 reference

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

1 reference

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Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

1 reference

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28 July 2018

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1 reference

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28 July 2018

Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation

1 reference

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28 July 2018

Jaks and Stats in cytokine signaling

1 reference

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28 July 2018

STATs and gene regulation

1 reference

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28 July 2018

Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts

1 reference

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28 July 2018

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site

1 reference

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28 July 2018

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1 reference

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28 July 2018

Constitutive activation of JAK1 in Src-transformed cells

1 reference

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28 July 2018

A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primordial germ cell growth or survival in culture.

1 reference

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28 July 2018

Expression of tyrosine kinase gene in mouse thymic stromal cells

1 reference

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28 July 2018

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

1 reference

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28 July 2018

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

1 reference

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28 July 2018

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

1 reference

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28 July 2018

Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

1 reference

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28 July 2018

Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Activation and association of Stat3 with Src in v-Src-transformed cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

A tyrosine kinase profile of prostate carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Receptor protein-tyrosine kinases and their signal transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding

1 reference

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28 July 2018

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

1 reference

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Production of high-titer helper-free retroviruses by transient transfection

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28 July 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

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Role of LFB3 in Cell-specific cAMP Induction of the Urokinase-type Plasminogen Activator Gene

1 reference

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The MAPK signaling cascade

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28 July 2018

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

1 reference

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28 July 2018

Jak-STAT signaling induced by the v-abl oncogene

1 reference

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28 July 2018

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

1 reference

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28 July 2018

Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein

1 reference

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The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter

1 reference

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28 July 2018

A novel putative tyrosine kinase receptor with oncogenic potential

1 reference

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28 July 2018

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=116068

28 July 2018

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

1 reference

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28 July 2018

A novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences

1 reference

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28 July 2018

Activation of c-Src in cells bearing v-Crk and its suppression by Csk

1 reference

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28 July 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

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28 July 2018

The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis

1 reference

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Rat cell line 3y1 and its virogenic polyoma- and SV40-transformed derivatives

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28 July 2018

Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.

1 reference

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29 October 2018

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

1 reference

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29 October 2018

Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase

1 reference

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1 reference

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1 reference

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1 reference

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Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

1 reference

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1 reference

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1 reference

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1 reference

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GAS6 induces Axl-mediated chemotaxis of vascular smooth muscle cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/MCB.19.2.1401

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891073%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891073%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9891073%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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