The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation (Q34346107)

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Language	Label	Description	Also known as
English	The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

K Chiba

1

1 reference

Europe PubMed Central

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1 August 2017

A Saitoh

2

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Europe PubMed Central

PubMed publication ID

1 August 2017

E Koyama

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

M Tani

4

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Europe PubMed Central

PubMed publication ID

1 August 2017

M Hayashi

5

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Europe PubMed Central

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1 August 2017

T Ishizaki

6

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1 August 2017

language of work or name

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publication date

1 March 1994

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Europe PubMed Central

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1 August 2017

British Journal of Clinical Pharmacology

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Europe PubMed Central

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1 August 2017

37

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Europe PubMed Central

PubMed publication ID

1 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

237-242

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Europe PubMed Central

PubMed publication ID

1 August 2017

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Genetically variable metabolism of antidepressants and neuroleptic drugs in man.

1 reference

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6 July 2018

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

A pharmacokinetic analysis program (multi) for microcomputer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Plasma levels and clinical response with imipramine in a study comparing efficacy with mianserin and nomifensine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Slow omeprazole metabolizers are also poor S-mephenytoin hydroxylators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Nonlinear kinetics of imipramine in low and medium plasma level ranges.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Clinical pharmacokinetics of imipramine and desipramine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Inhibitors of imipramine metabolism by human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364753

6 July 2018

Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetic characterization of S-mephenytoin 4-hydroxylase (P-450IICMP) activity in human liver samples obtained as surgical waste from Japanese patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and preliminary application of a simple assay of S-mephenytoin 4-hydroxylase activity in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical implications of imipramine plasma levels for depressive illness

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between plasma antidepressant levels and clinical outcome for inpatients receiving imipramine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8198931

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.1994.TB04269.X

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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