Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. (Q34473854)

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Language	Label	Description	Also known as
English	Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.	scientific article

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21 February 2020

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease (English)

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21 February 2020

Alzheimer's disease

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GOA release 2020-03-11

cellular response to amyloid-beta

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GOA release 2020-03-11

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GOA release 2020-03-11

1

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21 February 2020

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21 February 2020

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Mingke Song

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21 February 2020

Xia Liu

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21 February 2020

Seong Su Kang

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21 February 2020

Il-Sun Kwon

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21 February 2020

Duc M Duong

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21 February 2020

Nicholas T Seyfried

7

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21 February 2020

Zhixue Liu

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21 February 2020

Jian-Zhi Wang

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21 February 2020

Liming Cheng

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21 February 2020

Yi E Sun

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21 February 2020

Shan Ping Yu

13

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21 February 2020

Allan I Levey

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21 February 2020

Keqiang Ye

15

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21 February 2020

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19 October 2014

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21 February 2020

Nature Medicine

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21 February 2020

20

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21 February 2020

11

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21 February 2020

1254-1262

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21 February 2020

Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease

1 reference

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6 July 2018

SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease

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6 July 2018

Asparaginyl endopeptidase cleaves TDP-43 in brain

1 reference

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6 July 2018

Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration

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6 July 2018

Proteolytic processing of tau.

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6 July 2018

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice

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Systematical optimization of reverse-phase chromatography for shotgun proteomics

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6 July 2018

Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease

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6 July 2018

Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

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6 July 2018

Differential regulation of dynein and kinesin motor proteins by tau

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6 July 2018

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

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Culturing hippocampal neurons

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Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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6 July 2018

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

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6 July 2018

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

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6 July 2018

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

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6 July 2018

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo

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6 July 2018

Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

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6 July 2018

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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6 July 2018

Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

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Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration.

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6 July 2018

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

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6 July 2018

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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6 July 2018

Altered microtubule organization in small-calibre axons of mice lacking tau protein

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6 July 2018

Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability.

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6 July 2018

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

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6 July 2018

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Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

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Characterization of tau in cerebrospinal fluid using mass spectrometry.

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Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

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27 October 2018

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Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

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27 October 2018

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

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Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation

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27 October 2018

The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

1 reference

https://api.crossref.org/works/10.1038%2FNM.3700

7 January 2021

based on heuristic

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10.1038/NM.3700

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21 February 2020

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21 February 2020

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21 February 2020

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