Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial (Q34798154)

4 August 2017

title

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial (English)

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4 August 2017

main subject

phase I clinical trial

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Delphine Boche

2

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Ghasem Yadegarfar

object named as

Ghasem Yadegarfar

4

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Clive Holmes

object named as

Clive Holmes

1

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Roy W Jones

7

object named as

Roy W Jones

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David Wilkinson

3

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Vivienne Hopkins

5

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Anthony Bayer

6

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Roger Bullock

8

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Seth Love

9

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James W Neal

10

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Elina Zotova

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James A R Nicoll

12

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language of work or name

English

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publication date

1 July 2008

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4 August 2017

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4 August 2017

volume

372

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issue

9634

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4 August 2017

page(s)

216-223

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Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

4 August 2017

cites work

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

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Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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A specific amyloid-beta protein assembly in the brain impairs memory

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Identifiers

DOI

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4 August 2017

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