Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers (Q38450314)

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scientific article published on January 1, 2003

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English	Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers	scientific article published on January 1, 2003

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

title

Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers (English)

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

main subject

endocrinology

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Crossref

DOI

10.1007/S12022-003-0014-2

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https://api.crossref.org/works/10.1007/S12022-003-0014-2

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26 March 2024

Merkel cell carcinoma

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author

Marco Volante

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3

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Marco Volante

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

Mauro Papotti

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2

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Mauro Papotti

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

author name string

Long Jin

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4

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

Lori A. Erickson

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1

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Europe PubMed Central

PubMed publication ID

14586067

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14586067

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26 March 2024

Jean E. Lewis

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5

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PubMed publication ID

14586067

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14586067

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26 March 2024

Ricardo V. Lloyd

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6

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Europe PubMed Central

PubMed publication ID

14586067

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14586067

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26 March 2024

language of work or name

English

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publication date

1 January 2003

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PubMed publication ID

14586067

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3 September 2017

full work available at URL

http://link.springer.com/content/pdf/10.1007/s12022-003-0014-2.pdf

file format

Portable Document Format

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DOI

10.1007/S12022-003-0014-2

reference URL

https://api.crossref.org/works/10.1007/S12022-003-0014-2

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26 March 2024

http://link.springer.com/article/10.1007/s12022-003-0014-2/fulltext.html

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HTML

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Crossref

DOI

10.1007/S12022-003-0014-2

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https://api.crossref.org/works/10.1007/S12022-003-0014-2

retrieved

26 March 2024

http://link.springer.com/content/pdf/10.1007/s12022-003-0014-2

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Crossref

DOI

10.1007/S12022-003-0014-2

reference URL

https://api.crossref.org/works/10.1007/S12022-003-0014-2

retrieved

26 March 2024

published in

Endocrine Pathology

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Europe PubMed Central

PubMed publication ID

14586067

retrieved

3 September 2017

volume

14

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

issue

3

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

page(s)

221-229

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Europe PubMed Central

PubMed publication ID

14586067

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3 September 2017

cites work

p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS12022-003-0014-2

retrieved

21 January 2018

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS12022-003-0014-2

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21 January 2018

Immunohistochemical Staining for DNA Topoisomerase II in Non-Hodgkin’s Lymphomas

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https://api.crossref.org/works/10.1007%2FS12022-003-0014-2

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21 January 2018

DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage.

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Crossref

reference URL

https://api.crossref.org/works/10.1007%2FS12022-003-0014-2

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21 January 2018

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGFB, TGFB Receptors, Ki-67, and p27(Kip)l Expression in Papillary Thyroid Carcinomas

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroendocrine carcinoma within lymph nodes in the absence of a primary tumor, with special reference to Merkel cell carcinoma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skp2 is oncogenic and overexpressed in human cancers

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutaneous neuroendocrine (Merkel cell) carcinoma: an immunophenotypic, clinicopathologic, and flow cytometric study

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokeratin staining in Merkel cell carcinoma: an immunohistochemical study of cytokeratins 5/6, 7, 17, and 20.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of thyroid transcription factor-1 and cytokeratin 20 separates merkel cell carcinoma from small cell carcinoma of lung

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Over-expression of p45(SKP2) in Kaposi's sarcoma correlates with higher tumor stage and extracutaneous involvement but is not directly related to p27(KIP1) down-regulation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant p27kip1 expression in endocrine and other tumors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete spontaneous regression of Merkel cell carcinoma: a review of the 10 reported cases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin E-CDK2 is a regulator of p27Kip1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G1 control in mammalian cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of antikeratin antibodies in the immunohistochemical distinction between neuroendocrine (Merkel cell) carcinoma of the skin, lymphoma, and oat cell carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation markers and prognosis in Merkel cell carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hyperplasia, adenomas, and carcinomas: differential expression of p27Kip1 protein

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical analysis of p27/kip1 expression in thyroid carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary nodal neuroendocrine (Merkel cell) tumor in a patient with HIV infection

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymph node Merkel cell carcinoma with no evidence of cutaneous tumor--report of two cases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/14586067

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S12022-003-0014-2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

14586067

retrieved

3 September 2017

Dimensions Publication ID

1017426342

0 references

PubMed publication ID

14586067

1 reference

stated in

Europe PubMed Central

PubMed publication ID

14586067

retrieved

3 September 2017

 

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