Pages that link to "Q28250886"
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The following pages link to Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia (Q28250886):
Displaying 50 items.
- The Janus kinases (Jaks) (Q21194856) (← links)
- Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation (Q24522820) (← links)
- TYK2 is a key regulator of the surveillance of B lymphoid tumors (Q24559982) (← links)
- Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities (Q24792628) (← links)
- Native interface of the SAM domain polymer of TEL. (Q24801634) (← links)
- Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation (Q24806655) (← links)
- JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications (Q26782539) (← links)
- Targeting JAK2 in the therapy of myeloproliferative neoplasms (Q26860796) (← links)
- The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia (Q27266125) (← links)
- Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression (Q27633822) (← links)
- Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights (Q28078210) (← links)
- Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitor (Q28482297) (← links)
- Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta (Q28506708) (← links)
- CUL-4A is critical for early embryonic development (Q28594730) (← links)
- ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5 (Q28609080) (← links)
- Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway (Q28776380) (← links)
- Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation (Q33559005) (← links)
- Jak2 inhibitors: rationale and role as therapeutic agents in hematologic malignancies (Q33586552) (← links)
- STAT signaling in the pathogenesis and treatment of cancer (Q33712802) (← links)
- The 8p11 myeloproliferative syndrome (Q33865411) (← links)
- Lnk constrains myeloproliferative diseases in mice (Q33882944) (← links)
- Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes (Q33889476) (← links)
- Mechanisms of transformation by the BCR/ABL oncogene (Q33946147) (← links)
- The molecular regulation of Janus kinase (JAK) activation (Q33956113) (← links)
- TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. (Q33964993) (← links)
- A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition (Q34065882) (← links)
- Jaks and stats as therapeutic targets (Q34071332) (← links)
- JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells (Q34087180) (← links)
- Kinase mutations in human disease: interpreting genotype-phenotype relationships (Q34088851) (← links)
- Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events (Q34113046) (← links)
- Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity (Q34181347) (← links)
- Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core. (Q34181360) (← links)
- Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase (Q34182738) (← links)
- Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation (Q34245259) (← links)
- Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3). (Q34270442) (← links)
- Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis (Q34281241) (← links)
- Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia (Q34486039) (← links)
- t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5. (Q34570939) (← links)
- Stat proteins and oncogenesis (Q34627064) (← links)
- Gene mutations and molecularly targeted therapies in acute myeloid leukemia. (Q34647741) (← links)
- Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies (Q34718163) (← links)
- Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma (Q34754714) (← links)
- Canonical and non-canonical JAK-STAT signaling (Q34855617) (← links)
- Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia (Q34955618) (← links)
- JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein (Q34968444) (← links)
- Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele (Q35005652) (← links)
- Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo (Q35120026) (← links)
- Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments. (Q35201333) (← links)
- The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow (Q35206654) (← links)
- Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. (Q35258501) (← links)