Activin A receptor like type 1 (Q4650909)

TGFβ superfamily receptor

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

GS domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

activin binding

1 reference

24 April 2018

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

transforming growth factor beta-activated receptor activity

1 reference

24 April 2018

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

3 references

8 April 2019

8 April 2019

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Regulation of ALK-1 signaling by the nuclear receptor LXRbeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

protein binding

12 references

8 April 2019

Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Regulation of ALK-1 signaling by the nuclear receptor LXRbeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

BMP receptor activity

1 reference

24 April 2018

Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

8 April 2019

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

protein kinase binding

1 reference

8 April 2019

Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

transforming growth factor beta binding

1 reference

8 April 2019

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

transforming growth factor beta receptor activity, type I

1 reference

24 April 2018

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

activin receptor activity, type I

1 reference

24 April 2018

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

SMAD binding

1 reference

24 April 2018

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

transforming growth factor beta-activated receptor activity

transforming growth factor beta receptor activity, type I

activin receptor activity, type I

growth factor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

SMAD binding

activin binding

BMP receptor activity

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

integral component of plasma membrane

1 reference

24 April 2018

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

neuronal cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

8 April 2019

Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

integral component of plasma membrane

receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

activin receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of cell adhesion

biological process

1 reference

8 April 2019

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

regulation of transcription, DNA-templated

1 reference

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

positive regulation of endothelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

blood vessel morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

regulation of DNA replication

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

endothelial tube morphogenesis

1 reference

8 April 2019

Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

wound healing, spreading of epidermal cells

1 reference

8 April 2019

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

positive regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

cellular response to BMP stimulus

negative regulation of endothelial cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

blood circulation

1 reference

8 April 2019

Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

positive regulation of angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of endothelial cell migration

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

regulation of blood pressure

1 reference

8 April 2019

Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of cell migration

1 reference

8 April 2019

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

transmembrane receptor protein serine/threonine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

1 reference

8 April 2019

negative regulation of cell growth

1 reference

8 April 2019

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

positive regulation of chondrocyte differentiation

1 reference

8 April 2019

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

angiogenesis

Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

regulation of endothelial cell proliferation

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

transforming growth factor beta receptor signaling pathway

2 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

24 April 2018

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P37023&geneProductId=UniProtKB:P37023

negative regulation of focal adhesion assembly

1 reference

8 April 2019

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of DNA biosynthetic process

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

signal transduction

1 reference

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

negative regulation of cell population proliferation

1 reference

8 April 2019

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

blood vessel maturation

1 reference

8 April 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

activin receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

endocardial cushion to mesenchymal transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

positive regulation of transcription by RNA polymerase II

ISS

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

BMP signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

3 references

8 April 2019

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

transforming growth factor beta receptor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

pattern specification process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P37023

protein kinase, ATP binding site

Gene Atlas image

PBB GE ACVRL1 210838 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

protein kinase domain

1 reference

serine/threonine-protein kinase, active site

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

GS domain

1 reference