Thyroid stimulating hormone receptor (Q4862366)

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mammalian protein found in Homo sapiens

seven transmembrane helix receptor
thyrotropin receptor-I, hTSHR-I
thyrotropin receptor
TSHR
Thyroid-stimulating hormone receptor
TSH receptor
TSH-R

Language	Label	Description	Also known as
English	Thyroid stimulating hormone receptor	mammalian protein found in Homo sapiens	seven transmembrane helix receptor thyrotropin receptor-I, hTSHR-I thyrotropin receptor TSHR Thyroid-stimulating hormone receptor TSH receptor TSH-R

Statements

1 reference

13 November 2019

UniProt protein ID

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16473

Thyrotropin receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16473

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

BspA type Leucine rich repeat region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

G protein-coupled peptide receptor activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

protein-hormone receptor activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

signal transducer activity

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

thyroid-stimulating hormone receptor activity

determination method or standard

3 references

27 March 2018

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

27 March 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

signaling receptor activity

determination method or standard

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

thyroid-stimulating hormone receptor activity

determination method or standard

4 references

8 April 2019

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

receptor complex

determination method or standard

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

27 March 2018

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

integral component of plasma membrane

determination method or standard

biological process

cell-cell signaling

determination method or standard

1 reference

8 April 2019

Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method or standard

1 reference

8 April 2019

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

positive regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

activation of adenylate cyclase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

hormone-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

nervous system development

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

positive regulation of adenylate cyclase activity

determination method or standard

1 reference

1 January 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

determination method or standard

cellular response to glycoprotein

determination method or standard

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

cellular response to thyrotropin-releasing hormone

determination method or standard

1 reference

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

thyroid-stimulating hormone signaling pathway

determination method or standard

1 reference

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method or standard

positive regulation of cold-induced thermogenesis

determination method or standard

1 reference

8 April 2019

Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

determination method or standard

physically interacts with

thyrotropin alfa

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201533

Gene Atlas image

PBB GE TSHR 210055 at fs.png
732 × 530; 10 KB

0 references

http://purl.uniprot.org/uniprot/P16473

1 reference

Identifiers.org

BspA type Leucine rich repeat region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16473

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16473

thyrotropin-releasing hormone

1 reference

imported from Wikimedia project

English Wikipedia

Wikimedia import URL

https://en.wikipedia.org/w/index.php?title=Thyrotropin_receptor&oldid=950607596

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000340113

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000340113

ENSP00000450549

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450549

ENSP00000298171

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000298171

ENSP00000441235

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441235

ENSP00000451092

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451092

ENSP00000451202

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000451202

ENSP00000490136

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490136

ENSP00000495625

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495625

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(12 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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