Cyclin dependent kinase 8 (Q5198254)

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mammalian protein found in Homo sapiens

cell division protein kinase 8
CDK8 protein kinase
protein kinase K35
cyclin-dependent kinase 8
mediator complex subunit CDK8
CDK8
mediator of RNA polymerase II transcription subunit CDK8

Language	Label	Description	Also known as
English	Cyclin dependent kinase 8	mammalian protein found in Homo sapiens	cell division protein kinase 8 CDK8 protein kinase protein kinase K35 cyclin-dependent kinase 8 mediator complex subunit CDK8 CDK8 mediator of RNA polymerase II transcription subunit CDK8

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49336

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

protein binding

determination method or standard

14 references

8 April 2019

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

CDK8 is a positive regulator of transcriptional elongation within the serum response network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

Cyclin C is a haploinsufficient tumour suppressor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

The protein interaction landscape of the human CMGC kinase group

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

RNA polymerase II CTD heptapeptide repeat kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

protein serine/threonine kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

determination method or standard

1 reference

8 April 2019

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

protein-containing complex

determination method or standard

1 reference

8 April 2019

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

mediator complex

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

biological process

regulation of transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

protein phosphorylation

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336

determination method or standard

transcription initiation from RNA polymerase II promoter

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336

determination method or standard

regulation of mitotic cell cycle

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49336&geneProductId=UniProtKB:P49336

determination method or standard

regulation of cell cycle

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49336

determination method or standard

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Gene Atlas image

PBB GE CDK8 204831 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P49336

1 reference

Identifiers.org

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49336

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49336

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49336

Identifiers

MeSH descriptor ID

subject named as

Cyclin-Dependent Kinase 8

0 references

D05.500.374.500

0 references

D08.811.913.696.620.682.700.646.500.968

0 references

D12.776.157.057.072.500

0 references

D12.776.167.200.548

0 references

D12.776.476.024.388.500

0 references

D12.776.476.563.646.500.968

0 references

D12.776.660.551.500

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000370938

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370938

ENSP00000437696

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437696

ENSP00000485883

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485883

ENSP00000487013

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487013

PDB structure ID

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

UniProt protein ID

15 June 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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