RuvB like AAA ATPase 1 (Q7383575)

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mammalian protein found in Homo sapiens

RuvB-like AAA ATPase
epididymis secretory sperm binding protein
pontin 52
RuvB (E coli homolog)-like 1
nuclear matrix protein 238
TIP60-associated protein 54-alpha
49 kDa TBP-interacting protein
TAP54-alpha
TIP49a
TATA binding protein interacting protein 49 kDa
RUVBL1
NMP 238
ECP-54
ruvB-like 1
54 kDa erythrocyte cytosolic protein
49 kDa TATA box-binding protein-interacting protein
INO80 complex subunit H

Language	Label	Description	Also known as
English	RuvB like AAA ATPase 1	mammalian protein found in Homo sapiens	RuvB-like AAA ATPase epididymis secretory sperm binding protein pontin 52 RuvB (E coli homolog)-like 1 nuclear matrix protein 238 TIP60-associated protein 54-alpha 49 kDa TBP-interacting protein TAP54-alpha TIP49a TATA binding protein interacting protein 49 kDa RUVBL1 NMP 238 ECP-54 ruvB-like 1 54 kDa erythrocyte cytosolic protein 49 kDa TATA box-binding protein-interacting protein INO80 complex subunit H

Statements

1 reference

13 November 2019

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y265

RuvB-like helicase 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y265

1 reference

based on heuristic

inferred from protein domain or family

TIP49, P-loop domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

5'-3' DNA helicase activity

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

helicase activity

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

ATPase activity

determination method or standard

1 reference

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

protein binding

determination method or standard

17 references

31 October 2017

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A High-Density Map for Navigating the Human Polycomb Complexome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

hydrolase activity

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

cadherin binding

determination method or standard

1 reference

31 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

TFIID-class transcription factor complex binding

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

DNA helicase activity

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

NuA4 histone acetyltransferase complex

determination method or standard

determination method or standard

microtubule organizing center

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

extracellular exosome

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

3 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

ANP32E is a histone chaperone that removes H2A.Z from chromatin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

31 October 2017

A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

biological process

DNA recombination

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

positive regulation of protein targeting to mitochondrion

determination method or standard

1 reference

31 October 2017

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

histone H2A acetylation

determination method or standard

1 reference

31 October 2017

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

regulation of transcription by RNA polymerase II

determination method or standard

1 reference

31 October 2017

Identification and characterization of the ubiquitously occurring nuclear matrix protein NMP 238

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

CENP-A containing chromatin assembly

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

regulation of autophagy of mitochondrion

determination method or standard

1 reference

31 October 2017

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

spermatogenesis

determination method or standard

1 reference

31 October 2017

TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

positive regulation of telomerase RNA localization to Cajal body

determination method or standard

1 reference

31 October 2017

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

histone H4 acetylation

determination method or standard

1 reference

31 October 2017

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

regulation of growth

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

beta-catenin-TCF complex assembly

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

DNA duplex unwinding

determination method or standard

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

protein deubiquitination

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

determination method or standard

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

box C/D snoRNP assembly

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

chromatin remodeling

determination method or standard

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y265&geneProductId=UniProtKB:Q9Y265

determination method or standard

Gene Atlas image

PBB GE RUVBL1 201614 s at fs.png
732 × 530; 12 KB

0 references

TIP49, P-loop domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y265

AAA+ ATPase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y265

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000318297

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000318297

ENSP00000417254

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417254

ENSP00000417370

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417370

ENSP00000420738

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420738

ENSP00000463669

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463669

ENSP00000496354

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496354

ENSP00000494621

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494621

ENSP00000496149

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496149

ENSP00000494625

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494625

ENSP00000495296

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495296

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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