Just dual boot your Mac into Windows (you can get a cheap license key from somewhere like CJS-CDKeys) and eGPU if needed. I'm using a Quest/PC combo and Low-Fi plays quite smoothly given it's still in development
This is the sort of game that would work really well in VR too (and there's a great shortage of story driven single player campaigns for VR so could have a really good niche). At any rate looking forward to seeing more either way
Virtual Desktop has just released a Mac beta so you should have potential to use your Quest wirelessly via Mac. In fact if your Mac is VR ready you can try this now