FRMD6

FRMD6
Identifiers
Aliases	FRMD6, C14orf31, EX1, Willin, c14_5320, FERM domain containing 6
External IDs	OMIM: 614555; MGI: 2442579; HomoloGene: 12449; GeneCards: FRMD6; OMA:FRMD6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q22.1 Start 51,489,100 bp End 51,730,727 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C2 Start 70,872,288 bp End 70,949,008 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm cartilage tissue tibia tail of epididymis stromal cell of endometrium epithelium of lactiferous gland lactiferous duct oral cavity skin of thigh skin of hip Top expressed in calvaria skin of external ear hair follicle ankle joint body of femur skin of back corneal stroma lip conjunctival fornix sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of cytoskeleton Cellular component apical junction complex plasma membrane membrane cytoplasm cytoskeleton Biological process regulation of actin filament-based process apical constriction actomyosin structure organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 122786 319710 Ensembl ENSG00000139926 ENSMUSG00000048285 UniProt Q96NE9 Q8C0V9 RefSeq (mRNA) NM_001042481 NM_001267046 NM_001267047 NM_152330 NM_028127 RefSeq (protein) NP_001035946 NP_001253975 NP_001253976 NP_689543 NP_082403 Location (UCSC) Chr 14: 51.49 – 51.73 Mb Chr 12: 70.87 – 70.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.

Further reading

• Kronenberg NM, Tilston-Lunel A, Thompson FE, Chen D, Yu W, Dholakia K, Gather MC, Gunn-Moore FJ (2020). "Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity". Frontiers in Cellular Neuroscience. 14: 552213. doi:10.3389/fncel.2020.552213. PMC 7498650. PMID 33088261.
• Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. Bibcode:2013PLoSO...860028M. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.
• Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. hdl:10023/2489. PMID 21666719.
• Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828. S2CID 32305188.
• Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207. S2CID 15468669.
• Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'" (PDF). FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.