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'''Uncharacterized protein LOC399693 '''is a protein in humans that is encoded by the 10 exon gene''' ''MGC50722 '''''on chromosome 9q34.<ref name=":2">{{Cite web|url = http://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=613410221|title = MGC50722 uncharacterized MGC50722 [Homo sapiens (human)]|date = |accessdate = |website = NCBI Gene|publisher = |last = |first = }}</ref><ref name=":0">{{Cite web|url = http://www.ncbi.nlm.nih.gov/protein/613410221|title = Homo sapiens uncharacterized protein LOC399693|date = |accessdate = |website = NCBI Protein|publisher = |last = |first = }}</ref> <span>Initially ''MGC50722'' was amongst 15,000 genes identified through the Mammalian Gene Collection (MGC) Program Team.</span><ref>{{Cite journal|url = |title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences|last = |first = |date = 2002-12-24|journal = Proceedings of the National Academy of Sciences of the United States of America|doi = 10.1073/pnas.242603899|pmid = 12477932|access-date = |volume = 99|issue = 26|pages = 16899–16903}}</ref><span> The gene is shown to be conserved in chimps, rhesus monkeys, dogs, cows, mice, and rats, while also having orthologs in 28 organisms. This 965 amino acid protein is encoded by a 3,596 bp mRNA, has a molecular weight of 104,495 Da, and an isoelectric point of 10.4954.</span><ref name=":0" /><ref>{{Cite web|url = http://www.ncbi.nlm.nih.gov/nuccore/NM_001291516.1|title = Homo sapiens uncharacterized MGC50722 (MGC50722), transcript variant 1, mRNA|date = |accessdate = |website = NCBI Nucleotide|publisher = |last = |first = }}</ref><ref name=":1">{{Cite web|url = http://useast.ensembl.org/Homo_sapiens/Transcript/ProteinSummary?db=core;g=ENSG00000260220;r=9:136280942-136306901;t=ENST00000569961|title = Transcript: MGC50722-001 ENST00000569961 Protein Summary|date = |accessdate = |website = Ensembl|publisher = |last = |first = }}</ref> An interesting feature present in the protein is Domain of Unknown Function 390 (DUF390), which has been found in the rice genome and may be some kind of transposable element.<ref name=":0" /><ref>{{Cite web|url = http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=112890|title = pfam04094: DUF390|date = |accessdate = |website = NCBI Structure|publisher = |last = |first = }}</ref> Programs have also identified two regions within the amino acid sequence that are coiled-coils (N-coils).<ref name=":1" /> <span>Currently, Uncharacterized Protein LOC399693 is shown to be expressed in human brain, lung, and testis tissue.</span><ref>{{Cite web|url = http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?UGID=1204650&TAXID=9606&SEARCH=Hs.530383|title = Uncharacterized MGC50722 (MGC50722)|date = |accessdate = |website = NCBI UniGene|publisher = |last = |first = }}</ref><ref>{{Cite journal|url = |title = Characteristics of 292 Testis-Specific Genes in Human|last = Tang et al.|first = |date = 2007|journal = Biological and Pharmaceutical Bulletin|doi = 10.1248/bpb.30.865|pmid = |access-date = |volume = 30|issue = 5}}</ref> |
'''Uncharacterized protein LOC399693 '''is a protein in humans that is encoded by the 10 exon gene''' ''MGC50722 '''''on chromosome 9q34.<ref name=":2">{{Cite web|url = http://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=613410221|title = MGC50722 uncharacterized MGC50722 [Homo sapiens (human)]|date = |accessdate = |website = NCBI Gene|publisher = |last = |first = }}</ref><ref name=":0">{{Cite web|url = http://www.ncbi.nlm.nih.gov/protein/613410221|title = Homo sapiens uncharacterized protein LOC399693|date = |accessdate = |website = NCBI Protein|publisher = |last = |first = }}</ref> <span>Initially ''MGC50722'' was amongst 15,000 genes identified through the Mammalian Gene Collection (MGC) Program Team.</span><ref>{{Cite journal|url = |title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences|last = |first = |date = 2002-12-24|journal = Proceedings of the National Academy of Sciences of the United States of America|doi = 10.1073/pnas.242603899|pmid = 12477932|access-date = |volume = 99|issue = 26|pages = 16899–16903}}</ref><span> The gene is shown to be conserved in chimps, rhesus monkeys, dogs, cows, mice, and rats, while also having orthologs in 28 organisms. This 965 amino acid protein is encoded by a 3,596 bp [[Messenger RNA|mRNA]], has a molecular weight of 104,495 Da, and an [[Isoelectric point|isoelectric point]] of 10.4954.</span><ref name=":0" /><ref>{{Cite web|url = http://www.ncbi.nlm.nih.gov/nuccore/NM_001291516.1|title = Homo sapiens uncharacterized MGC50722 (MGC50722), transcript variant 1, mRNA|date = |accessdate = |website = NCBI Nucleotide|publisher = |last = |first = }}</ref><ref name=":1">{{Cite web|url = http://useast.ensembl.org/Homo_sapiens/Transcript/ProteinSummary?db=core;g=ENSG00000260220;r=9:136280942-136306901;t=ENST00000569961|title = Transcript: MGC50722-001 ENST00000569961 Protein Summary|date = |accessdate = |website = Ensembl|publisher = |last = |first = }}</ref> An interesting feature present in the protein is Domain of Unknown Function 390 (DUF390), which has been found in the rice genome and may be some kind of [[Transposable element|transposable element]].<ref name=":0" /><ref>{{Cite web|url = http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=112890|title = pfam04094: DUF390|date = |accessdate = |website = NCBI Structure|publisher = |last = |first = }}</ref> Programs have also identified two regions within the amino acid sequence that are [[Coiled coil|coiled-coils]] (N-coils).<ref name=":1" /> <span>Currently, Uncharacterized Protein LOC399693 is shown to be expressed in human brain, lung, and testis tissue.</span><ref>{{Cite web|url = http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?UGID=1204650&TAXID=9606&SEARCH=Hs.530383|title = Uncharacterized MGC50722 (MGC50722)|date = |accessdate = |website = NCBI UniGene|publisher = |last = |first = }}</ref><ref>{{Cite journal|url = |title = Characteristics of 292 Testis-Specific Genes in Human|last = Tang et al.|first = |date = 2007|journal = Biological and Pharmaceutical Bulletin|doi = 10.1248/bpb.30.865|pmid = |access-date = |volume = 30|issue = 5}}</ref> |
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== Gene == |
== Gene == |
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Revision as of 13:31, 14 April 2015
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Uncharacterized protein LOC399693 is a protein in humans that is encoded by the 10 exon gene MGC50722 on chromosome 9q34.[1][2] Initially MGC50722 was amongst 15,000 genes identified through the Mammalian Gene Collection (MGC) Program Team.[3] The gene is shown to be conserved in chimps, rhesus monkeys, dogs, cows, mice, and rats, while also having orthologs in 28 organisms. This 965 amino acid protein is encoded by a 3,596 bp mRNA, has a molecular weight of 104,495 Da, and an isoelectric point of 10.4954.[2][4][5] An interesting feature present in the protein is Domain of Unknown Function 390 (DUF390), which has been found in the rice genome and may be some kind of transposable element.[2][6] Programs have also identified two regions within the amino acid sequence that are coiled-coils (N-coils).[5] Currently, Uncharacterized Protein LOC399693 is shown to be expressed in human brain, lung, and testis tissue.[7][8]
Gene
![[icon]](http://upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Wiki_letter_w_cropped.svg/40px-Wiki_letter_w_cropped.svg.png){kind=small} | This section is empty. You can help by adding to it. (April 2015) |
Homology and evolution
Paralog Space
Ortholog Space
Evolutionary History
Protein
Protein Internal Structure
| Feature | Residue Span |
|---|---|
| DUF390[1][9] | 405-690 |
| Region of Low Complexity[5] | 11-26 |
| Region of Low Complexity[5] | 410-423 |
| Region of Low Complexity[5] | 546-556 |
| Coiled-Coil[5] | 546-566 |
| Region of Low Complexity[5] | 606-621 |
| Coiled-Coil[5] | 720-753 |
| Region of Low Complexity[5] | 771-791 |
| Region of Low Complexity[5] | 871-884 |
Potential Function and Biochemistry
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Expression
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Clinical significance
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Related Papers
The Neonatal Ventromedial Hypothalamus Transcriptome Reveals Novel Markers with Spatially Distinct Patterning[10]
Chromosome Abnormalities in Sperm from Infertile Men with Normal Somatic Karyotypes: Teratozoospermia[11]
Neural Mechanisms of Extinction Learning and Retrieval[12]
Neurophysiology and Cognitive Functions of the Striatum[13]
Evolutionary analysis of mammalian genomes and associations to human disease[14]
References
- ^ a b "MGC50722 uncharacterized MGC50722 [Homo sapiens (human)]". NCBI Gene.
- ^ a b c "Homo sapiens uncharacterized protein LOC399693". NCBI Protein.
- ^ "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. 2002-12-24. doi:10.1073/pnas.242603899. PMID 12477932.
- ^ "Homo sapiens uncharacterized MGC50722 (MGC50722), transcript variant 1, mRNA". NCBI Nucleotide.
- ^ a b c d e f g h i j "Transcript: MGC50722-001 ENST00000569961 Protein Summary". Ensembl.
- ^ "pfam04094: DUF390". NCBI Structure.
- ^ "Uncharacterized MGC50722 (MGC50722)". NCBI UniGene.
- ^ Tang; et al. (2007). "Characteristics of 292 Testis-Specific Genes in Human". Biological and Pharmaceutical Bulletin. 30 (5). doi:10.1248/bpb.30.865.
{{cite journal}}: Explicit use of et al. in:|last=(help) - ^ "Conserved Protein Domain Family DUF390".
- ^ Kurrasch, Deborah M (December 12, 2007). "The Neonatal Ventromedial Hypothalamus Transcriptome Reveals Novel Markers with Spatially Distinct Patterning". The Journal of Neuroscience. doi:10.1523/JNEUROSCI.2858-07.2007.
- ^ Machev, N (2005). "Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: teratozoospermia". Cytogenetic and Genome Research. doi:10.1159/000086910.
- ^ Quirk, Gregory J. (January 2008). "Neural Mechanisms of Extinction Learning and Retrieval". Neuropsychopharmacology. doi:10.1038/sj.npp.1301555.
- ^ Rolls, E.T. (August 1994). "Neurophysiology and cognitive functions of the striatum". Revue Neurologique. PMID 7754303.
- ^ Vamathevan, J.J. (January 2009). "Evolutionary analysis of mammalian genomes and associations to human disease". UCL (University College London).
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