There’s no surefire strategy for building a thriving start-up. Entrepreneurs have launched successful businesses using frameworks like the Business Model Canvas, the Balanced Scorecard, and more. But in a recent study involving young ventures in Europe, one technique consistently boosted performance. Firms employing the scientific method—the centuries-old discipline of formulating, testing, and tweaking hypotheses—generated more revenue than companies in a control group did and were more likely to pivot away from unviable ideas, a routine necessity for early-stage start-ups. And among the top revenue generators in the experiment, the differences were especially pronounced. Among the top 25%, start-ups using the scientific method generated €28,000 more than the control companies did over the course of the experiment, on average, and among the top 5%, they made €492,000 more.

A version of this article appeared in the July–August 2024 issue of Harvard Business Review.