Lysosoma

Schema cellulae typicae animalis, partes subcellulares ostendens. Organella: (1) nucleolus, (2) nucleus, (3) ribosoma, (4) vesicula, (5) reticulum endoplasmaticum granulosum, (6) apparatus Golgianus, (7) cytosceletus, (8) reticulum endoplasmaticum leve, (9) mitochondria, (10) vacuola, (11) cytoplasma, (12) **lysosoma**, (13) centriola.

Lysosoma^[1] (-atis, n.) (ex verbis Graecis λύσις solutio et σῶμα corpus compositum) est organellum in cellulis animalibus inventum, quod enzyma hydrolytica includit, ut materias vastas et reliquias cellulares dissolvat. In fermentis^? et plantis, vacuola lytica eandem functionem gerunt.^[2]

Dysfunctio lysosomatum in morbis neurodegenerativus inventa est^[3].

Formatio

In exordio omnis lysosomatis primo pars systematis endomembranosis in vesiculam formatur (lysosoma primarium), deinde in apparatu Golgiano enzymos in reticulo endoplasmatico fabricatos (hydrolases) otbinet. Paulo ante hanc conexionem mannosum-6-phosphatum accepit. Per fusionem cum endosomate sero (pH 5.5) tandem fit lysosoma maturum.

Notae

↑ International Committee on Veterinary Histological Nomenclature (1994). Nomina Histologica. Turici/Ithacae/Novi Eboraci.
↑ Samaj J, Read ND, Volkmann D, Menzel D, Baluska F (August 2005). "The endocytic network in plants". Trends Cell Biol. 15 (8): 425–33
↑ Root J., Merino P., Nuckols A., Johnson M., Kukar T. (Iul 2021). "Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis". Neurobiology of disease 154: 105360

Nexus interni

Glucocerebrosidasis

stipula

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[NAV1994-1] International Committee on Veterinary Histological Nomenclature (1994). Nomina Histologica. Turici/Ithacae/Novi Eboraci.

[2] Samaj J, Read ND, Volkmann D, Menzel D, Baluska F (August 2005). "The endocytic network in plants". Trends Cell Biol. 15 (8): 425–33

[3] Root J., Merino P., Nuckols A., Johnson M., Kukar T. (Iul 2021). "Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis". Neurobiology of disease 154: 105360

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