Metazolamid
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| (IUPAC) ime
|
| N-[5-(aminosulfonil)-3-metil-1,3,4-tiadiazol-2(3H)-iliden]acetamid
|
| Klinički podaci
|
| AHFS/Drugs.com
|
Monografija
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| MedlinePlus
|
a601233
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| Identifikatori
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| CAS broj
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554-57-4
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| ATC kod
|
S01EC05
|
| PubChem[1][2]
|
4100
|
| DrugBank
|
DB00703
|
| ChemSpider[3]
|
3958
|
| UNII
|
W733B0S9SD  Y
|
| KEGG[4]
|
D00655 Y
|
| ChEMBL[5]
|
CHEMBL19 Y
|
| Hemijski podaci
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| Formula
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C5H8N4O3S2
|
| Mol. masa
|
236,274 g/mol
|
| SMILES
|
eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4- Y
Key: FLOSMHQXBMRNHR-DAXSKMNVSA-N Y |
|
| Sinonimi
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N-(3-Metil-5-sulfamoil-3H-1,3,4-tiadiazol-2-iliden) etanamid
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| Farmakokinetički podaci
|
| Vezivanje za proteine plazme
|
55%
|
| Poluvreme eliminacije
|
14 sati
|
| Farmakoinformacioni podaci
|
| Trudnoća
|
C(US)
|
| Pravni status
|
℞-only (SAD)
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| Način primene
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Oralno
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Metazolamid (Neptazan) je inhibitor karbonatne dehidrataze.[6][7][8][9]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Iyer G, Bellantone R, Taft D (1999). „In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.”. J Pharmacokinet Biopharm 27 (1): 45–66. DOI:10.1023/A:1020630712388. PMID 10533697.
- ↑ RxList. „Neptazane”. Arhivirano iz originala na datum 2006-08-12. Pristupljeno 20. 8. 2006.
- ↑ Shirato S, Kagaya F, Suzuki Y, Joukou S (1997). „Stevens–Johnson syndrome induced by methazolamide treatment.”. Arch Ophthalmol 115 (4): 550–3. PMID 9109770.
- ↑ Skorobohach B, Ward D, Hendrix D (2003). „Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.”. Am J Vet Res 64 (2): 183–7. DOI:10.2460/ajvr.2003.64.183. PMID 12602587.
