Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice (Q44391131)

2 December 2017

title

Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice (English)

1 reference

2 December 2017

1 reference

Ken Yajima

1

1 reference

2 December 2017

Hiroshi Hirose

2

1 reference

2 December 2017

Haruhisa Fujita

3

1 reference

2 December 2017

Yoshiko Seto

4

1 reference

2 December 2017

Hiroshi Fujita

5

1 reference

2 December 2017

Kaname Ukeda

6

1 reference

2 December 2017

Kiichi Miyashita

7

1 reference

2 December 2017

Toshihide Kawai

8

1 reference

2 December 2017

Yukihiro Yamamoto

9

1 reference

2 December 2017

Takeo Ogawa

10

1 reference

2 December 2017

Taketo Yamada

11

1 reference

2 December 2017

Takao Saruta

12

1 reference

2 December 2017

publication date

1 May 2003

1 reference

American Journal of Physiology - Endocrinology and Metabolism

2 December 2017

published in

1 reference

2 December 2017

volume

284

1 reference

2 December 2017

issue

5

1 reference

2 December 2017

page(s)

E966-71

1 reference

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

2 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Insulin secretory defect in Zucker fa/fa rats is improved by ameliorating insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Pioglitazone Treatment for 7 Days Failed to Correct the Defect in Glucose Transport and Glucose Transporter Translocation in Obese Zucker Rat (fa/fa) Skeletal Muscle Plasma Membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of Zucker diabetic fatty rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Lowering of plasma glucose concentrations with bezafibrate in patients with moderately controlled NIDDM

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Improvement of glucose tolerance in NIDDM by clofibrate. Randomized double-blind study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Regulation of Lipoprotein Metabolism by Thiazolidinediones Occurs through a Distinct but Complementary Mechanism Relative to Fibrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Improved insulin sensitivity by bezafibrate in rats: relationship to fatty acid composition of skeletal-muscle triglycerides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Amelioration by KRP-297, a new thiazolidinedione, of impaired glucose uptake in skeletal muscle from obese insulin-resistant animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Bezafibrate reduces blood glucose in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Pioglitazone hydrochloride stimulates insulin secretion in HIT-T 15 cells by inducing Ca2+ influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. Troglitazone and Exogenous Insulin Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Regulation of fatty acid homeostasis in cells: novel role of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00149.2002

10.1152/AJPENDO.00149.2002

21 January 2018

Identifiers

DOI

1 reference

2 December 2017

1 reference