Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage (Q48384211)

11 February 2018

title

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage (English)

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11 February 2018

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Tong Cheng

1

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11 February 2018

Anthony L Petraglia

2

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11 February 2018

Zhang Li

3

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11 February 2018

Meenakshisundaram Thiyagarajan

4

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11 February 2018

Zhihui Zhong

5

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11 February 2018

Zhenhua Wu

6

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11 February 2018

Dong Liu

7

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11 February 2018

Sanjay B Maggirwar

8

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11 February 2018

Rashid Deane

9

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11 February 2018

José A Fernández

10

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11 February 2018

Barbra LaRue

11

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11 February 2018

John H Griffin

12

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11 February 2018

Michael Chopp

13

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11 February 2018

Berislav V Zlokovic

14

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11 February 2018

language of work or name

English

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publication date

29 October 2006

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11 February 2018

published in

Nature Medicine

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11 February 2018

volume

12

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11 February 2018

issue

11

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11 February 2018

page(s)

1278-1285

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11 February 2018

Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

cites work

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Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke

21 January 2018

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Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group

21 January 2018

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7 January 2021

Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator

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7 January 2021

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.

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7 January 2021

Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats

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7 January 2021

Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion

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7 January 2021

Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke.

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7 January 2021

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

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7 January 2021

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

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7 January 2021

Remodeling after stroke

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7 January 2021

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

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7 January 2021

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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7 January 2021

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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7 January 2021

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

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7 January 2021

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

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7 January 2021

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

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7 January 2021

Efficacy and safety of recombinant human activated protein C for severe sepsis

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7 January 2021

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

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7 January 2021

Functional recovery after embolic stroke in rodents by activated protein C.

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7 January 2021

Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat.

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7 January 2021

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

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7 January 2021

IKK mediates ischemia-induced neuronal death

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7 January 2021

The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen

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7 January 2021

Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling

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7 January 2021

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

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7 January 2021

Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling

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7 January 2021

Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window

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7 January 2021

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

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7 January 2021

Role of matrix metalloproteinases in delayed cortical responses after stroke

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7 January 2021

A simple method for isolation and characterization of mouse brain microvascular endothelial cells

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7 January 2021

Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model

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7 January 2021

PAR1 cleavage and signaling in response to activated protein C and thrombin.

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7 January 2021

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

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7 January 2021

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

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7 January 2021

Tissue plasminogen activator reduces neurological damage after cerebral embolism.

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7 January 2021

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

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7 January 2021

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

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7 January 2021

Tissue plasminogen activator and NMDA receptor cleavage

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7 January 2021

A rat model of focal embolic cerebral ischemia

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7 January 2021

Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration

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The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries

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7 January 2021

Identifiers

DOI

10.1038/NM1498

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11 February 2018

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11 February 2018