Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 (Q28587775)

31 January 2017

title

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 (English)

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31 January 2017

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GOA release 2020-03-11

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Huang Guo

1

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31 January 2017

Dong Liu

2

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31 January 2017

Harris Gelbard

3

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31 January 2017

Tong Cheng

4

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31 January 2017

Rae Insalaco

5

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31 January 2017

José A. Fernández

6

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31 January 2017

John H. Griffin

7

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31 January 2017

Berislav V. Zlokovic

8

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31 January 2017

language of work or name

English

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publication date

19 February 2004

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31 January 2017

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31 January 2017

volume

41

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31 January 2017

issue

4

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31 January 2017

page(s)

563–572

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Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

31 January 2017

cites work

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The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

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Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

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Protease-activated receptors

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Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

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Nitric oxide evoked p53-accumulation and apoptosis

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7 January 2021

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

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Thrombin signalling and protease-activated receptors

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PARticipation in inflammation

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Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

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p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus

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Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

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Signaling pathways involved in thrombin-induced cell protection

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Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

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Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model

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Retroactive pathway involving mitochondria in electroloaded cytochrome c-induced apoptosis. Protective properties of Bcl-2 and Bcl-XL

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Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke

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The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

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Role and regulation of p53 in depolarization-induced neuronal death.

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Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

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NMDA receptor pathways as drug targets

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Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

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Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging

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Tissue plasminogen activator and NMDA receptor cleavage

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The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apoptosis

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7 January 2021

p53-dependent cell death signaling in neurons

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7 January 2021

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

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PAR3 is a cofactor for PAR4 activation by thrombin

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The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

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7 January 2021

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

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7 January 2021

Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels

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7 January 2021

Mitochondria, AIF and caspases--rivaling for cell death execution.

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7 January 2021

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

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PAR1 signaling: more good than harm?

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Role of NF-κB in p53-mediated programmed cell death

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Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment

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Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

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7 January 2021

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

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7 January 2021

Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

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7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

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7 January 2021

Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons

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7 January 2021

Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins

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7 January 2021

Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids.

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7 January 2021

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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7 January 2021

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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7 January 2021

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

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7 January 2021

10.1016/S0896-6273(04)00019-4

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017