Fyn can partially substitute for Lck in T lymphocyte development (Q71814468)

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scientific article published on 01 November 1996

Language	Label	Description	Also known as
English	Fyn can partially substitute for Lck in T lymphocyte development	scientific article published on 01 November 1996

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

Fyn can partially substitute for Lck in T lymphocyte development (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

author name string

T Groves

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

P Smiley

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

M P Cooke

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

K Forbush

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

R M Perlmutter

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

C J Guidos

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

publication date

1 November 1996

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

417-428

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

A signaling pathway governing early thymocyte maturation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of the protein tyrosine kinase p56lck in T cell signaling and thymocyte development.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequences.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation events during thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Tyrosine kinase triggering in thymocytes undergoing positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Syk tyrosine kinase required for mouse viability and B-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Positive selection of CD4+ and CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Positive selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Receptors and signals in early thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell development in mice lacking the CD3-zeta/eta gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

T-cell development and selection in the intestinal epithelium

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Participation of CD4 coreceptor molecules in T-cell repertoire selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for Positive Selection of γδ Receptor-Bearing T Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Developmental regulation of lck gene expression in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(-/-)-immature thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980498-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1074-7613(00)80498-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8934569%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

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