TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck (Q71079176)

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16 October 2019

title

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck (English)

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16 October 2019

0 references

1

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16 October 2019

author name string

J M Ashe

2

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16 October 2019

R Abe

3

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16 October 2019

J B Bolen

4

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16 October 2019

A Singer

5

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16 October 2019

publication date

1 May 1996

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16 October 2019

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16 October 2019

volume

4

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16 October 2019

issue

5

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16 October 2019

page(s)

495-504

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

16 October 2019

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Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

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Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity

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Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes

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T cell activation by clustered tyrosine kinases

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Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

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Identification of a monoclonal antibody specific for a murine T3 polypeptide

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Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

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Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

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A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

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Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.

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Profound block in thymocyte development in mice lacking p56lck

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Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

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Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

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Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

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Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

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Identification of the components of the murine T cell antigen receptor complex

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Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

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The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

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7 January 2021

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

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Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

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F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling

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Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

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Regulation of Zap-70 by Src family tyrosine protein kinases in an antigen-specific T-cell line

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Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

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7 January 2021

Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes

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Identifiers

DOI

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16 October 2019

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