Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease (Q24564815)

1

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Hsin-Ping Liu

2

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Ann-Shyn Chiang

3

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Stephen A Hearn

4

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Mary Konsolaki

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

27 April 2004

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published in

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volume

101

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issue

17

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page(s)

6623-8

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cites work

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Alzheimer's disease is a synaptic failure

7 April 2017

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

7 April 2017

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

7 April 2017

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

27 September 2017

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Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

27 September 2017

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

27 September 2017

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Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis

27 September 2017

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

27 September 2017

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27 September 2017

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Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

27 September 2017

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

27 September 2017

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

27 September 2017

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The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

27 September 2017

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

27 September 2017

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High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy

27 September 2017

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

27 September 2017

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On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogaster

27 September 2017

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

27 September 2017

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Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies

30 May 2018

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Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease

30 May 2018

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Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies

30 May 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

30 May 2018

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Correlations of synaptic and pathological markers with cognition of the elderly

30 May 2018

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The carboxyl third of tau is tightly bound to paired helical filaments.

30 May 2018

1 reference

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Formation of beta-amyloid protein deposits in brains of transgenic mice

30 May 2018

1 reference

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Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene

30 May 2018

1 reference

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A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Identification and characterization of the Drosophila tau homolog.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

A neurofibromatosis-1-regulated pathway is required for learning in Drosophila

28 November 2018

1 reference

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Integrin-mediated short-term memory in Drosophila

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=404095

In vivo aggregation of beta-amyloid peptide variants

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15069204

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Classical conditioning and retention in normal and mutantDrosophila melanogaster

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15069204

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0400895101

1 reference

ADS bibcode

2004PNAS..101.6623I

0 references

1 reference

1 reference

PubMed publication ID

15069204

1 reference