Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration (Q28140796)

2

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M Nikolic

3

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S de la Monte

4

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P Dikkes

5

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L H Tsai

A family of human cdc2-related protein kinases

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language of work or name

English

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publication date

9 December 1999

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published in

Nature

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volume

402

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issue

6762

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page(s)

615-22

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cites work

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Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

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Callosal axon guidance defects in p35(-/-) mice

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

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Identification of functional domains in the neuronal Cdk5 activator protein

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The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

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The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning

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p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway

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Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro

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Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)

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Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5.

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Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain.

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Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra

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Expression of cell cycle-related genes during neuronal apoptosis: is there a distinct pattern?

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Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling

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Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions

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Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings

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Integrated evaluation of central nervous system lesions: stains for neurons, astrocytes, and microglia reveal the spatial and temporal features of MK-801-induced neuronal necrosis in the rat cerebral cortex

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