Magic bullets for protein kinases (Q34221212)

31 July 2017

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title

Magic bullets for protein kinases (English)

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31 July 2017

Bishop AC

1

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31 July 2017

Buzko O

series ordinal

2

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31 July 2017

Shokat KM

series ordinal

3

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31 July 2017

publication date

1 April 2001

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31 July 2017

published in

Trends in Cell Biology

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31 July 2017

volume

11

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31 July 2017

issue

4

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31 July 2017

page(s)

167-172

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Signaling--2000 and beyond

31 July 2017

cites work

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1001 protein kinases redux--towards 2000.

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Acquisition of inhibitor-sensitive protein kinases through protein design

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

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Unnatural ligands for engineered proteins: new tools for chemical genetics

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Engineering Src family protein kinases with unnatural nucleotide specificity

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Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

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Three-dimensional structure of the tyrosine kinase c-Src

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Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

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Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

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Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

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Structural basis for selective inhibition of Src family kinases by PP1

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A dual inhibitor of platelet-derived growth factor beta-receptor and Src kinase activity potently interferes with motogenic and mitogenic responses to PDGF in vascular smooth muscle cells. A novel candidate for prevention of vascular remodeling

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7 January 2021

Staurosporine, a Potentially Important Gift from a Microorganism

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7 January 2021

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes

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Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo.

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Cyclin-dependent kinases: engines, clocks, and microprocessors

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Rules to replicate by

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7 January 2021

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation

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7 January 2021

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

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Actin cytoskeleton organization regulated by the PAK family of protein kinases

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7 January 2021

Cell wall stress depolarizes cell growth via hyperactivation of RHO1.

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7 January 2021

A cell cycle checkpoint monitors cell morphogenesis in budding yeast

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7 January 2021

Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities

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7 January 2021

Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.

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Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

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7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

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7 January 2021

High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design

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7 January 2021

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

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7 January 2021

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Identifiers

DOI

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31 July 2017

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