The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4. (Q35326762)

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English	The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.	scientific article

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21 February 2020

The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4 (English)

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21 February 2020

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21 February 2020

Jacqueline M Matthews

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21 February 2020

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Soumya Joseph

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21 February 2020

Ann H Kwan

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21 February 2020

Philippa H Stokes

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Liza Cubeddu

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13 October 2014

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21 February 2020

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21 February 2020

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13 October 2014

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LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.

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Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex

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Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells

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Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor

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Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.

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27 July 2018

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

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Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity

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LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression

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Competition between LIM-binding domains

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Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland

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The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells

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The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.

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Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein

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27 July 2018

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

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27 July 2018

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27 July 2018

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex

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Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice

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The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity

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27 July 2018

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

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27 July 2018

Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators

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27 July 2018

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Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein

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27 July 2018

Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis

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27 July 2018

Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1

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21 January 2018

A positive role for NLI/Ldb1 in long-range beta-globin locus control region function

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21 January 2018

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21 January 2018

The LIM-only protein LMO4 modulates the transcriptional activity of HEN1

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21 January 2018

LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin

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21 January 2018

LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus.

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21 January 2018

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Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4

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21 January 2018

Identification of a nuclear export signal and protein interaction domains in deformed epidermal autoregulatory factor-1 (DEAF-1).

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21 January 2018

Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1.

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21 January 2018

Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP

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21 January 2018

DEAF-1 function is essential for the early embryonic development of Drosophila.

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21 January 2018

Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems

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Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays

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26 September 2018

LIM Domain Binding Proteins 1 and 2 Have Different Oligomeric States

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21 January 2018

Novel homozygous DEAF1 variant suspected in causing white matter disease, intellectual disability, and microcephaly

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12 December 2020

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21 February 2020

2014PLoSO...9j9108J

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21 February 2020

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