Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases (Q35772225)

10 August 2017

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title

Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases (English)

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10 August 2017

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2

Leppla SH

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10 August 2017

Gordon VM

1

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10 August 2017

language of work or name

English

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publication date

1 February 1994

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10 August 2017

published in

Infection and Immunity

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10 August 2017

volume

62

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10 August 2017

issue

2

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10 August 2017

page(s)

333-340

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PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

10 August 2017

cites work

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Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process

27 July 2018

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Activation of botulinum C2 toxin by trypsin

27 July 2018

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Identification of the carbohydrate receptor for Shiga toxin produced by Shigella dysenteriae type 1.

27 July 2018

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27 July 2018

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Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide

27 July 2018

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ADP-ribosylation of nonmuscle actin with component I of C2 toxin

27 July 2018

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Conformation of protein secreted across bacterial outer membranes: a study of enterotoxin translocation from Vibrio cholerae

27 July 2018

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ompT encodes the Escherichia coli outer membrane protease that cleaves T7 RNA polymerase during purification

27 July 2018

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Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.

27 July 2018

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Identity of molecular structure of Shiga-like toxin I (VT1) from Escherichia coli O157:H7 with that of Shiga toxin.

27 July 2018

1 reference

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Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

27 July 2018

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Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin

27 July 2018

1 reference

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Secretion, processing and activation of bacterial extracellular proteases

27 July 2018

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Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature

27 July 2018

1 reference

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Production by Clostridium spiroforme of an iotalike toxin that possesses mono(ADP-ribosyl)transferase activity: identification of a novel class of ADP-ribosyltransferases

27 July 2018

1 reference

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Domain II mutants of Pseudomonas exotoxin deficient in translocation

27 July 2018

1 reference

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Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Purification and characterization of a protease from Clostridium botulinum type A that nicks single-chain type A botulinum neurotoxin into the di-chain form

27 July 2018

1 reference

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Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

27 July 2018

1 reference

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Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically-cleavable spacer sequence

27 July 2018

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Botulinum neurotoxin type E fragmented with endoproteinase Lys-C reveals the site trypsin nicks and homology with tetanus neurotoxin

27 July 2018

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Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity

27 July 2018

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Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

27 July 2018

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Chains and fragments of tetanus toxin, and their contribution to toxicity

27 July 2018

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Mammalian subtilisins: the long-sought dibasic processing endoproteases

27 July 2018

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Immunotoxins containing ricin or its A chain

27 July 2018

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Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.

27 July 2018

1 reference

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Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Entry of diphtheria toxin-protein A chimeras into cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A and alphaviruses fails to cleave Sindbis virus glycoprotein PE2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Immunotoxins and cytokine toxin fusion proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Characterization of a cellular protease that cleaves Pseudomonas exotoxin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Limited proteolysis of single-chain tetanus toxin by tissue enzymes, in cultured brain tissue and during retrograde axonal to the spinal cord

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Serum protease cleavage of Bacillus anthracis protective antigen

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Recombinant toxins as novel therapeutic agents

27 July 2018

1 reference

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Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=186112

Botulinum neurotoxins are zinc proteins

27 July 2018

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The new enzymology of precursor processing endoproteases

27 July 2018

1 reference

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Visualizations of binding and internalization of two nonlinked protein components of botulinum C2 toxin in tissue culture cells

27 July 2018

1 reference

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

27 July 2018

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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

27 July 2018

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Construction of a new universal vector for insertional mutagenesis by homologous recombination

27 July 2018

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Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis

27 July 2018

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Biochemical and genetic characterization of three hamster cell mutants resistant to diphtheria toxin

27 July 2018

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Structure of tetanus toxin. Demonstration and separation of a specific enzyme converting intracellular tetanus toxin to the extracellular form

27 July 2018

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27 July 2018

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Subunit structure of Shigella cytotoxin.

27 July 2018

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Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

25 September 2018

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Activation of Clostridium botulinum type B toxin by an endogenous enzyme.

25 September 2018

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Limited proteolysis of tetanus toxin. Relation to activity and identification of cleavage sites

25 September 2018

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The crystal structure of diphtheria toxin

25 September 2018

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Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule

25 September 2018

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12 December 2020

Botulinum C2 toxin ADP-ribosylates actin

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12 December 2020

The processing of human proinsulin and chicken proalbumin by rat hepatic vesicles suggests a convertase specific for X-Y-Arg-Arg or Arg-X-Y-Arg sequences

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Anthrax toxin protective antigen: low-pH-induced hydrophobicity and channel formation in liposomes

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The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

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Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum

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12 December 2020

Specific cleavage of diphtheria toxin by human urokinase

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12 December 2020

Translocation of diphtheria toxin A-fragment to the cytosol. Role of the site of interfragment cleavage

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12 December 2020

A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo

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12 December 2020

Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking site

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Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

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Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

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pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen

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12 December 2020

Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule

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Characterization of the diphtheria toxin-resistance system in Chinese hamster ovary cells

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12 December 2020

Interaction between Clostridium botulinum neurotoxin and gangliosides

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12 December 2020

Separation and characterization of heavy and light chains from Clostridium botulinum type C toxin and their reconstitution

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12 December 2020

10.1128/IAI.62.2.333-340.1994

Identifiers

DOI

0 references

PMC publication ID

186112

1 reference

10 August 2017

1 reference