A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family. (Q36761494)

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scientific article published on January 2007

Language	Label	Description	Also known as
English	A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.	scientific article published on January 2007

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scholarly article

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27 December 2019

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A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family (English)

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27 December 2019

Nicholas J Schill

6

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27 December 2019

Richard A. Anderson

7

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27 December 2019

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Jessica N Heck

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27 December 2019

David L Mellman

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27 December 2019

Kun Ling

3

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27 December 2019

Yue Sun

4

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27 December 2019

Matthew P Wagoner

5

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27 December 2019

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1 January 2007

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27 December 2019

Critical Reviews in Biochemistry and Molecular Biology

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27 December 2019

42

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27 December 2019

1

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27 December 2019

15-39

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27 December 2019

ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis

1 reference

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A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages

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Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.

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The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

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21 January 2018

Phosphatidylinositol phosphate kinase type Igamma directly associates with and regulates Shp-1 tyrosine phosphatase.

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21 January 2018

Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis

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Phosphatidylinositol 4-kinases: old enzymes with emerging functions

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Phosphatidylinositol-4-phosphate 5-kinase-1beta is essential for epidermal growth factor receptor-mediated endocytosis

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PIP2 and PIP as determinants for ATP inhibition of KATP channels

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21 January 2018

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

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21 January 2018

The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases

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21 January 2018

Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors

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21 January 2018

Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis

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21 January 2018

The flattened face of type II beta phosphatidylinositol phosphate kinase binds acidic phospholipid membranes.

1 reference

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21 January 2018

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

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Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network

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Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation

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Significance of subnuclear localization of key players of inositol lipid cycle

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21 January 2018

Molecular architecture and functional model of the endocytic AP2 complex

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21 January 2018

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

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21 January 2018

Essential role of phosphoinositide metabolism in synaptic vesicle recycling

1 reference

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21 January 2018

Phosphatidylinositol transfer protein dictates the rate of inositol trisphosphate production by promoting the synthesis of PIP2

1 reference

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21 January 2018

PIP2 and PIP3: complex roles at the cell surface

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21 January 2018

PI-loting membrane traffic

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21 January 2018

Phosphoinositide lipid second messengers: new paradigms for calcium channel modulation

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21 January 2018

MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae.

1 reference

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21 January 2018

Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Unclear or nuclear: another role for the phosphatidylinositol cycle?

1 reference

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21 January 2018

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform beta 1 is specifically, but not predominantly, located in the nucleus

1 reference

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21 January 2018

Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane

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21 January 2018

Myoblasts Fuse When Loner Meets ARF6

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21 January 2018

Localization and function of Arf family GTPases

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21 January 2018

Regulators and effectors of the ARF GTPases.

1 reference

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21 January 2018

Phosphatidylinositol Phosphate Kinases Put PI4,5P 2 in Its Place

1 reference

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21 January 2018

Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

1 reference

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21 January 2018

Probing phosphoinositide functions in signaling and membrane trafficking.

1 reference

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21 January 2018

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

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21 January 2018

Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif

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21 January 2018

The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology.

1 reference

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Endocytosis by random initiation and stabilization of clathrin-coated pits

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Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body.

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The building blocks for basolateral vesicles in polarized epithelial cells.

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A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells

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Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes

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Intracellular localization of phospholipase D1 in mammalian cells

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Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits

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Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

1 reference

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Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

1 reference

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ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

1 reference

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ADP ribosylation factor regulates spectrin binding to the Golgi complex

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21 January 2018

ADP-ribosylation factor regulates spectrin skeleton assembly on the Golgi complex by stimulating phosphatidylinositol 4,5-bisphosphate synthesis

1 reference

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Nuclear phosphoinositide kinases and inositol phospholipids.

1 reference

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The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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21 January 2018

Receptors and phosphoinositide-generated second messengers

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Effects of acetylcholine on phosphate turnover in phospholipides of brain cortex in vitro

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Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices

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Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis

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Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

1 reference

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21 January 2018

Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.

1 reference

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

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Lipid metabolism and regulation of membrane trafficking

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21 January 2018

Nuclear lipid signalling

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Nuclear inositide signalling -- expansion, structures and clarification

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A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals

1 reference

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Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

1 reference

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Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly

1 reference

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Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment.

1 reference

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Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta

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21 January 2018

Adaptors for clathrin-mediated traffic

1 reference

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Clathrin adaptors really adapt

1 reference

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The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma

1 reference

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21 January 2018

Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes

1 reference

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Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice

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Cell migration: a physically integrated molecular process

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GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism

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Signaling and endocytosis: a team effort for cell migration

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21 January 2018

Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases

1 reference

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21 January 2018

Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.

1 reference

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21 January 2018

Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

1 reference

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21 January 2018

Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch

1 reference

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21 January 2018

Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.

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21 January 2018

A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus

1 reference

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21 January 2018

Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia

1 reference

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21 January 2018

Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family

1 reference

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21 January 2018

PI(4,5)P(2) regulation of surface membrane traffic

1 reference

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21 January 2018

Phosphatidylinositol 4,5-bisphosphate regulates two steps of homotypic vacuole fusion

1 reference

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21 January 2018

Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases

1 reference

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21 January 2018

PIP(2) and proteins: interactions, organization, and information flow

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21 January 2018

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

1 reference

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21 January 2018

Regulation of actin dynamics by WASP family proteins

1 reference

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21 January 2018

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

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21 January 2018

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast

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21 January 2018

Binding of basic peptides to acidic lipids in membranes: effects of inserting alanine(s) between the basic residues

1 reference

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21 January 2018

MARCKS regulates membrane ruffling and cell spreading

1 reference

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21 January 2018

Regulation of protein activities by phosphoinositide phosphates

1 reference

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21 January 2018

Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Adaptors for clathrin coats: structure and function.

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Sticky business: orchestrating cellular signals at adherens junctions

1 reference

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21 January 2018

Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Evolving nature of the AP2 alpha-appendage hub during clathrin-coated vesicle endocytosis

1 reference

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21 January 2018

Phosphoinositide signaling; from affinity probes to pharmaceutical targets

1 reference

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21 January 2018

Syndapin isoforms participate in receptor-mediated endocytosis and actin organization

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Molecular links between endocytosis and the actin cytoskeleton.

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

A phosphatidylinositol (4,5)-bisphosphate binding site within mu2-adaptin regulates clathrin-mediated endocytosis

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Phosphoinositides in constitutive membrane traffic.

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin

1 reference

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21 January 2018

The role of phosphoinositides in signal transduction

1 reference

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21 January 2018

Inhibition of phosphatidic acid synthesis alters the structure of the Golgi apparatus and inhibits secretion in endocrine cells

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

The role of phosphoinositides in membrane transport

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Fragmentation and re-assembly of the Golgi apparatus in vitro. A requirement for phosphatidic acid and phosphatidylinositol 4,5-bisphosphate synthesis

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

A template for the protein kinase family

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Structural framework for the protein kinase family

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Role of phosphoinositide signaling in the control of insulin exocytosis

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Phospholipid transfer proteins revisited

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Cell migration in tumors

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Phosphoinositide regulation of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Structure of Type IIβ Phosphatidylinositol Phosphate Kinase

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2as Being Important in Exocytosis

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

ARF6 GTPase controls bacterial invasion by actin remodelling

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

The Effector Domain of Myristoylated Alanine-rich C Kinase Substrate Binds Strongly to Phosphatidylinositol 4,5-Bisphosphate

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Regulation of the association of membrane skeletal protein 4.1 with glycophorin by a polyphosphoinositide

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1 reference

https://api.crossref.org/works/10.1080%2F10409230601162752

21 January 2018

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