Targeting the Nrf2 pathway against cardiovascular disease (Q37521075)

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scientific article published on July 2009

Language	Label	Description	Also known as
English	Targeting the Nrf2 pathway against cardiovascular disease	scientific article published on July 2009

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

1 reference

Europe PubMed Central

Targeting the Nrf2 pathway against cardiovascular disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

cardiovascular disease

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based on heuristic

inferred from title

author name string

Jinqing Li

1

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Tomonaga Ichikawa

2

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Joseph S Janicki

3

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Taixing Cui

4

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

language of work or name

0 references

publication date

1 July 2009

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Expert Opinion on Therapeutic Targets

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Europe PubMed Central

PubMed publication ID

20 August 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

785-794

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Europe PubMed Central

PubMed publication ID

20 August 2017

Aging: a theory based on free radical and radiation chemistry

1 reference

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21 January 2018

Free radicals in the physiological control of cell function

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system

1 reference

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21 January 2018

Vascular NADPH oxidases as drug targets for novel antioxidant strategies

1 reference

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21 January 2018

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

1 reference

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21 January 2018

Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial

1 reference

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21 January 2018

Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality

1 reference

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21 January 2018

Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nuclear import and export signals in control of Nrf2.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Mechanistic studies of the Nrf2-Keap1 signaling pathway

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Molecular mechanisms of Nrf2-mediated antioxidant response

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2, a multi-organ protector?

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothelium

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals

1 reference

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21 January 2018

Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

CD36 and macrophages in atherosclerosis

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes

1 reference

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21 January 2018

Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice

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21 January 2018

Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo

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21 January 2018

Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction

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21 January 2018

Thioredoxin in the cardiovascular system

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21 January 2018

Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress

1 reference

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21 January 2018

Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury

1 reference

https://api.crossref.org/works/10.1517%2F14728220903025762

21 January 2018

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

1 reference

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21 January 2018

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Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.

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Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

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Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials

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Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

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Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

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21 January 2018

Free Radicals in Biological Materials

1 reference

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21 January 2018

Identifiers

10.1517/14728220903025762

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

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