Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. (Q36796876)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17446857%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

review article

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title

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (English)

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29 December 2019

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1

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29 December 2019

author name string

Mark M Yore

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17446857%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Michael B Sporn

series ordinal

3

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29 December 2019

language of work or name

English

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publication date

19 April 2007

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29 December 2019

published in

Nature Reviews Cancer

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29 December 2019

volume

7

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29 December 2019

issue

5

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29 December 2019

page(s)

357-369

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The consensus coding sequences of human breast and colorectal cancers

29 December 2019

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A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

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The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance

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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action

31 March 2020

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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

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31 March 2020

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The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

31 March 2020

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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

31 March 2020

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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

31 March 2020

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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

31 March 2020

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Cancer chemoprevention: scientific promise, clinical uncertainty

31 March 2020

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31 March 2020

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Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

31 March 2020

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Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.

31 March 2020

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The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells

31 March 2020

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BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.

31 March 2020

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c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

31 March 2020

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The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway

31 March 2020

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The triterpenoid CDDO induces apoptosis in refractory CLL B cells

31 March 2020

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Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression

31 March 2020

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Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy

31 March 2020

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Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

31 March 2020

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A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

31 March 2020

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Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation

31 March 2020

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Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.

31 March 2020

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The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells

31 March 2020

1 reference

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

31 March 2020

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Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity

31 March 2020

1 reference

Reactive oxygen species in cancer cells: live by the sword, die by the sword.

31 March 2020

1 reference

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells

31 March 2020

1 reference

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

31 March 2020

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Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells

31 March 2020

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The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells

31 March 2020

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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

31 March 2020

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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

31 March 2020

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CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.

31 March 2020

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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

31 March 2020

1 reference

Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).

31 March 2020

1 reference

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells

31 March 2020

1 reference

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta

31 March 2020

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Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

31 March 2020

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Apoptosis as a novel target for cancer chemoprevention

31 March 2020

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31 March 2020

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31 March 2020

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Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

31 March 2020

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The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice

31 March 2020

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PPAR gamma and human metabolic disease

31 March 2020

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The many faces of PPARgamma

31 March 2020

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NF-kappaB: linking inflammation and immunity to cancer development and progression

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling

31 March 2020

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A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis

31 March 2020

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The STATs of cancer--new molecular targets come of age

31 March 2020

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Stat3 regulates genes common to both wound healing and cancer

31 March 2020

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Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

31 March 2020

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2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis

31 March 2020

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Redox-dependent transcriptional regulation

31 March 2020

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

31 March 2020

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

31 March 2020

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Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection

31 March 2020

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Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

31 March 2020

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Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2

31 March 2020

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Protein tyrosine phosphatases: from genes, to function, to disease

31 March 2020

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Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets

31 March 2020

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A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

31 March 2020

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Toxic potential of materials at the nanolevel

31 March 2020

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15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors

31 March 2020

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Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA

31 March 2020

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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

31 March 2020

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Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

31 March 2020

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Prospects for plant-derived chemopreventive agents exhibiting multiple mechanisms of action

31 March 2020

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Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

31 March 2020

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Nuclear receptor that identifies a novel retinoic acid response pathway

31 March 2020

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A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

31 March 2020

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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

31 March 2020

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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

31 March 2020

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The RXR heterodimers and orphan receptors

31 March 2020

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Nuclear receptors and lipid physiology: opening the X-files

31 March 2020

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Chemoprevention: an essential approach to controlling cancer

31 March 2020

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Retinoid x receptor heterodimers in the metabolic syndrome

31 March 2020

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Why do cancers have high aerobic glycolysis?

31 March 2020

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Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis

31 March 2020

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Bexarotene: a clinical review

31 March 2020

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Nonclassical retinoids and lung carcinogenesis

31 March 2020

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Retinoids selective for retinoid X receptor response pathways

31 March 2020

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Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids

31 March 2020

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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

31 March 2020

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Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes

31 March 2020

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Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes

31 March 2020

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Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids

31 March 2020

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Design, synthesis and structure-activity relationship of novel RXR-selective modulators

31 March 2020

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Structure-based design of potent retinoid X receptor alpha agonists

31 March 2020

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Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes

31 March 2020

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Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade

31 March 2020

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Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid

31 March 2020

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The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention

31 March 2020

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The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer

31 March 2020

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Bexarotene and erlotinib for aerodigestive tract cancer

31 March 2020

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Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays

31 March 2020

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Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

31 March 2020

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31 March 2020

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Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer

31 March 2020

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Multi-institutional phase I/II trial of oral bexarotene in combination with cisplatin and vinorelbine in previously untreated patients with advanced non-small-cell lung cancer

31 March 2020

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Dichotomies in cancer research: some suggestions for a new synthesis

31 March 2020

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Effect of the retinoid X receptor-selective ligand LGD1069 on mammary carcinoma after tamoxifen failure

31 March 2020

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Synergistic effect of a retinoid X receptor-selective ligand bexarotene (LGD1069, Targretin) and paclitaxel (Taxol) in mammary carcinoma

31 March 2020

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Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis

31 March 2020

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The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer

31 March 2020

1 reference

The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells

31 March 2020

1 reference

A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours

31 March 2020

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Prevention of mouse lung tumors by targretin

31 March 2020

1 reference

A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced prostate cancer

31 March 2020

1 reference

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

31 March 2020

1 reference

The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma

31 March 2020

1 reference

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

31 March 2020

1 reference

Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells

31 March 2020

1 reference

A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines

31 March 2020

1 reference

The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes

31 March 2020

1 reference

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

31 March 2020

1 reference

Inflammation in atherosclerosis

31 March 2020

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Mast cells in autoimmune disease

31 March 2020

1 reference

Inflammation and therapeutic vaccination in CNS diseases

31 March 2020

1 reference

The immunopathogenesis of sepsis

31 March 2020

1 reference

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

31 March 2020

1 reference

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

31 March 2020

1 reference

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

31 March 2020

1 reference

In vivo modulation of the Parkinsonian phenotype by Nrf2.

31 March 2020

1 reference

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A

31 March 2020

1 reference

2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways

31 March 2020

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