Protein tyrosine phosphatases: from genes, to function, to disease (Q29614826)

Europe PubMed Central

title

Protein tyrosine phosphatases: from genes, to function, to disease (English)

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30 April 2017

author name string

Tonks NK

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1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17057753

30 April 2017

language of work or name

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30 April 2017

publication date

November 2006

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=17057753

Nature Reviews Molecular Cell Biology

30 April 2017

published in

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volume

7

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issue

11

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page(s)

833-46

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Mathematical models of protein kinase signal transduction.

30 April 2017

cites work

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Principles behind the multifarious control of signal transduction

31 March 2020

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Signal transduction: an eye on organ development.

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A phosphatase for cofilin to be HAD.

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Sac phosphatase domain proteins.

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Protein tyrosine phosphatases in the human genome

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A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage

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Structural and evolutionary relationships among protein tyrosine phosphatase domains

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Cloning of hOST-PTP: the only example of a protein-tyrosine-phosphatase the function of which has been lost between rodent and human.

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Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase alpha.

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Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions

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Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases

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Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface

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Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition

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PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

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A Tyr/Ser protein phosphatase encoded by vaccinia virus

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Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin

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Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase

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Mammalian capping enzyme binds RNA and uses protein tyrosine phosphatase mechanism

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The structure and regulation of myotubularin phosphatases

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Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains

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The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production

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Crystal structure of the tandem phosphatase domains of RPTP LAR

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LKB1-dependent signaling pathways

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JAKing up hematopoietic proliferation

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Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases

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Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase

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The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease

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Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9

31 March 2020

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Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma

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Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase

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Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization

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Switching signals on or off by receptor dimerization

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Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases

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Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45

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Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge

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An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

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The juxtamembrane wedge negatively regulates CD45 function in B cells.

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CD45: a critical regulator of signaling thresholds in immune cells

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Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

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Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta

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Pleiotrophin stimulates tyrosine phosphorylation of beta-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase beta/zeta.

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Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP

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Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.

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Cellular signaling by fibroblast growth factor receptors

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Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma

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The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase

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The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development

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The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR

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Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation

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Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain

31 March 2020

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Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth

31 March 2020

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Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth

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Oxidant signals and oxidative stress

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NOX enzymes and the biology of reactive oxygen

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Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

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Redox regulation of protein-tyrosine phosphatases

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Functions and mechanisms of redox regulation of cysteine-based phosphatases

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Redox redux: revisiting PTPs and the control of cell signaling

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Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

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Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

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H2O2-induced intermolecular disulfide bond formation between receptor protein-tyrosine phosphatases

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Differential oxidation of protein-tyrosine phosphatases.

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Role of insulin-induced reactive oxygen species in the insulin signaling pathway

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Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

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Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes.

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Protein-tyrosine phosphatases and cancer

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Cdc25 phosphatases and cancer

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

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Stops along the RAS pathway in human genetic disease

31 March 2020

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

31 March 2020

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Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

31 March 2020

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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

31 March 2020

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PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis

31 March 2020

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Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

31 March 2020

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Identification of substrates of human protein-tyrosine phosphatase PTPN22

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

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PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

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Allosteric inhibition of protein tyrosine phosphatase 1B.

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Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function

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Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.

31 March 2020

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

31 March 2020

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Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

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Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O.

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Dimerization of receptor protein-tyrosine phosphatase alpha in living cells

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Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

31 March 2020

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Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress

31 March 2020

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Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers

31 March 2020

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Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

31 March 2020

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Mutational analysis of the tyrosine phosphatome in colorectal cancers

31 March 2020

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Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

31 March 2020

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Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

31 March 2020

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Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer

31 March 2020

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STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

31 March 2020

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Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma

31 March 2020

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Promoter methylation of the PTEN gene is a common molecular change in breast cancer

31 March 2020

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Abrogation of DUSP6 by hypermethylation in human pancreatic cancer

31 March 2020

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

31 March 2020

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Noonan syndrome and related disorders: genetics and pathogenesis

31 March 2020

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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

31 March 2020

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SHP2 forecast for the immune system: fog gradually clearing

31 March 2020

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Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

31 March 2020

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

31 March 2020

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Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene

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PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

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Interconversion of the kinetic identities of the tandem catalytic domains of receptor-like protein-tyrosine phosphatase PTPalpha by two point mutations is synergistic and substrate-dependent.

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Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

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Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

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Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

31 March 2020

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Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP

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Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts.

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The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal.

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Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes

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Subcellular targeting of oxidants during endothelial cell migration

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Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons

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Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

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The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway

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Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation

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Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion.

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Redox-dependent downregulation of Rho by Rac.

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31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2318363

Dimensions Publication ID

1021713482

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OpenCitations bibliographic resource ID

2318363

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