Rab27 effectors, pleiotropic regulators in secretory pathways. (Q38107224)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678941%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Rab27 effectors, pleiotropic regulators in secretory pathways (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678941%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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1

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1 March 2020

author name string

Mitsunori Fukuda

series ordinal

1

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29 August 2017

publication date

10 June 2013

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1 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678941%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678941%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23678941%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

949-963

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Rab GTPases as coordinators of vesicle traffic

1 March 2020

cites work

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Role of Rab GTPases in membrane traffic and cell physiology

21 January 2018

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21 January 2018

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TBC proteins: GAPs for mammalian small GTPase Rab?

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Thousands of rab GTPases for the cell biologist

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Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos

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The Rab8 GTPase regulates apical protein localization in intestinal cells

21 January 2018

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Griscelli syndrome: a model system to study vesicular trafficking

21 January 2018

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Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families.

21 January 2018

1 reference

Regulation of secretory vesicle traffic by Rab small GTPases

21 January 2018

1 reference

A general role for Rab27a in secretory cells

21 January 2018

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Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane

21 January 2018

1 reference

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

21 January 2018

1 reference

Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms

21 January 2018

1 reference

Rab27a and Rab27b control different steps of the exosome secretion pathway

21 January 2018

1 reference

Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression.

21 January 2018

1 reference

The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain

21 January 2018

1 reference

The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase

21 January 2018

1 reference

Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.

21 January 2018

1 reference

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.

21 January 2018

1 reference

Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets

21 January 2018

1 reference

Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.

21 January 2018

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The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane

21 January 2018

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Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse

21 January 2018

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Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.

21 January 2018

1 reference

Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells

21 January 2018

1 reference

Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain

21 January 2018

1 reference

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells

21 January 2018

1 reference

Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.

21 January 2018

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A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

21 January 2018

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Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells

21 January 2018

1 reference

The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.

21 January 2018

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Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex

21 January 2018

1 reference

Molecular mechanism of myosin Va recruitment to dense core secretory granules

21 January 2018

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The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules

21 January 2018

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Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis

21 January 2018

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Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a

21 January 2018

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Neurexin-1α contributes to insulin-containing secretory granule docking

21 January 2018

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Granuphilin molecularly docks insulin granules to the fusion machinery.

21 January 2018

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Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

21 January 2018

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ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis

21 January 2018

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The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells

21 January 2018

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Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner

21 January 2018

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The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.

21 January 2018

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Involvement of Rab27b in the Regulated Secretion of Pituitary Hormones

21 January 2018

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Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.

21 January 2018

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Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells

21 January 2018

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Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis

21 January 2018

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Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism

21 January 2018

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Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism.

21 January 2018

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Synaptotagmin-mediated vesicle fusion regulates cell migration

21 January 2018

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Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells

21 January 2018

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The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells

21 January 2018

1 reference

Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans

21 January 2018

1 reference

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport

21 January 2018

1 reference

Identification of an organelle receptor for myosin-Va

21 January 2018

1 reference

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport

21 January 2018

1 reference

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes

21 January 2018

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The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes

21 January 2018

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A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.

21 January 2018

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Missense mutations in the globular tail of myosin-Va in dilute mice partially impair binding of Slac2-a/melanophilin

21 January 2018

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Melanophilin and myosin Va track the microtubule plus end on EB1

21 January 2018

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Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice

21 January 2018

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A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat.

21 January 2018

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Zebrafish melanophilin facilitates melanosome dispersion by regulating dynein

21 January 2018

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A noncoding melanophilin gene (MLPH) SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs

21 January 2018

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A single point-mutation within the melanophilin gene causes the lavender plumage colour dilution phenotype in the chicken

21 January 2018

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Cellular and clinical report of new Griscelli syndrome type III cases

21 January 2018

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Slac2-a/melanophilin contains multiple PEST-like sequences that are highly sensitive to proteolysis

21 January 2018

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Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility

21 January 2018

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MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes

21 January 2018

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Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin

21 January 2018

1 reference

Functional analysis of Slac2-c/MyRIP as a linker protein between melanosomes and myosin VIIa.

21 January 2018

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The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium

21 January 2018

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Analysis of the linkage of MYRIP and MYO7A to melanosomes by RAB27A in retinal pigment epithelial cells

21 January 2018

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Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

21 January 2018

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Cargo binding activates myosin VIIA motor function in cells

21 January 2018

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Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration

21 January 2018

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Myosin 5a controls insulin granule recruitment during late-phase secretion

21 January 2018

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MyRIP anchors protein kinase A to the exocyst complex

21 January 2018

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Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis

21 January 2018

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MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway.

21 January 2018

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Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites

21 January 2018

1 reference

The small GTPase Rab27B regulates amylase release from rat parotid acinar cells

21 January 2018

1 reference

Redistribution of Rab27-specific effector Slac2-c, but not Slp4-a, after isoproterenol-stimulation in rat parotid acinar cells

21 January 2018

1 reference

Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane.

21 January 2018

1 reference

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.

21 January 2018

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Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells

21 January 2018

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TLR4-mediated expulsion of bacteria from infected bladder epithelial cells

21 January 2018

1 reference

The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis

21 January 2018

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A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells

21 January 2018

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Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells

21 January 2018

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Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells

21 January 2018

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Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

21 January 2018

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The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

21 January 2018

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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

21 January 2018

1 reference

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

1 reference

Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes

21 January 2018

1 reference

Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.

21 January 2018

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Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis

21 January 2018

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Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells

21 January 2018

1 reference

Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells

21 January 2018

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Munc13-4 regulates granule secretion in human neutrophils

21 January 2018

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Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils

21 January 2018

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Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

21 January 2018

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A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis

21 January 2018

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The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines

21 January 2018

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Rab27a, actin and beta-cell endocytosis

21 January 2018

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Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases

21 January 2018

1 reference

Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a

21 January 2018

1 reference

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2

21 January 2018

1 reference

Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain

21 January 2018

1 reference

The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.

21 January 2018

1 reference

Role of Rab27 in synaptic transmission at the squid giant synapse

21 January 2018

1 reference

Systematic discovery of Rab GTPases with synaptic functions in Drosophila

21 January 2018

1 reference

Exosome secretion: molecular mechanisms and roles in immune responses

21 January 2018

1 reference

Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression

21 January 2018

1 reference

An integrated approach to uncover drivers of cancer.

21 January 2018

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Deregulation of Rab and Rab effector genes in bladder cancer.

21 January 2018

1 reference

Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma

21 January 2018

1 reference

Enhanced expression of Rab27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II.

21 January 2018

1 reference

Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

21 January 2018

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Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis

21 January 2018

1 reference

Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion

21 January 2018

1 reference

Divide and polarize: recent advances in the molecular mechanism regulating epithelial tubulogenesis

21 January 2018

1 reference

Rab27b regulates mast cell granule dynamics and secretion

21 January 2018

1 reference

Novel myosin heavy chain encoded by murine dilute coat colour locus

21 January 2018

1 reference

Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

21 January 2018

1 reference

A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

21 January 2018

1 reference

Rab27a regulates the peripheral distribution of melanosomes in melanocytes

21 January 2018

1 reference

Rab27a: A key to melanosome transport in human melanocytes

21 January 2018

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

21 January 2018

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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

21 January 2018

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Rab27 and its effectors in secretory granule exocytosis: a novel docking machinery composed of a Rab27.effector complex

21 January 2018

1 reference

Munc 18-1 and granuphilin collaborate during insulin granule exocytosis

21 January 2018

1 reference

Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins

21 January 2018

1 reference

Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins

21 January 2018

1 reference

uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways.

21 January 2018

1 reference

Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.

21 January 2018

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Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding

21 January 2018

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Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets

21 January 2018

1 reference

Identification of EPI64 as a GTPase-activating protein specific for Rab27A

21 January 2018

1 reference

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

21 January 2018

1 reference

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity

21 January 2018

1 reference

EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells

21 January 2018

1 reference

Redistribution of small GTP-binding protein, Rab27B, in rat parotid acinar cells after stimulation with isoproterenol.

21 January 2018

1 reference

Rab GTPases, intracellular traffic and disease.

21 January 2018

1 reference

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

21 January 2018

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Mutations in GDI1 are responsible for X-linked non-specific mental retardation

21 January 2018

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Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

21 January 2018

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Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction

21 January 2018

1 reference

Rab27b regulates number and secretion of platelet dense granules

21 January 2018

1 reference

Distinct Rab27A binding affinities of Slp2-a and Slac2-a/melanophilin: Hierarchy of Rab27A effectors

21 January 2018

1 reference

Rab27a is required for human cytomegalovirus assembly

21 January 2018

1 reference

Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells

21 January 2018

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Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes

21 January 2018

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Recruitment of Rab27a to phagosomes controls microbial antigen cross-presentation by dendritic cells.

21 January 2018

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Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes

21 January 2018

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NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages

21 January 2018

1 reference