Pages that link to "Q81469973"
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The following pages link to An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone (Q81469973):
Displaying 50 items.
- Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer (Q24293323) (← links)
- Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin (Q24299666) (← links)
- Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells (Q24310510) (← links)
- AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids (Q24314550) (← links)
- Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily (Q24323295) (← links)
- The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (Q24613957) (← links)
- Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3 (Q27671816) (← links)
- Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer (Q27676555) (← links)
- Structure of AKR1C3 with 3-phenoxybenzoic acid bound (Q27678541) (← links)
- WOMEN IN CANCER THEMATIC REVIEW: Circadian rhythmicity and the influence of 'clock' genes on prostate cancer (Q28077467) (← links)
- High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells (Q29249058) (← links)
- Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers (Q33587153) (← links)
- Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment (Q33600379) (← links)
- Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer (Q33823702) (← links)
- New frontiers in androgen biosynthesis and metabolism. (Q34100727) (← links)
- Intratumoral steroidogenesis in castration-resistant prostate cancer: a target for therapy (Q34294888) (← links)
- Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library (Q34375275) (← links)
- Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism (Q34382405) (← links)
- Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up (Q34498106) (← links)
- Steroid hormone transforming aldo-keto reductases and cancer (Q34571239) (← links)
- Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights. (Q34618859) (← links)
- Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1) (Q34669224) (← links)
- Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. (Q34795526) (← links)
- Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation. (Q35013689) (← links)
- New hormonal therapies for castration-resistant prostate cancer (Q35196715) (← links)
- The aldo-keto reductases (AKRs): Overview (Q35305934) (← links)
- Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors (Q35532230) (← links)
- Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3). (Q35554014) (← links)
- Role of aldo-keto reductase enzymes in mediating the timing of parturition (Q35660367) (← links)
- Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships (Q35816836) (← links)
- Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride. (Q35869909) (← links)
- Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats (Q36037910) (← links)
- Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC). (Q36055229) (← links)
- Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer. (Q36585622) (← links)
- A Role for the PPARgamma in Cancer Therapy. (Q36691611) (← links)
- Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors (Q36937170) (← links)
- Current advances in intratumoral androgen metabolism in castration-resistant prostate cancer. (Q36970812) (← links)
- Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications (Q37159878) (← links)
- AKR1C3 as a target in castrate resistant prostate cancer (Q37248854) (← links)
- Aldo-Keto Reductase AKR1C1-AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy. (Q37698258) (← links)
- Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin. (Q38340921) (← links)
- Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. (Q38754094) (← links)
- Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation. (Q39649162) (← links)
- Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review (Q47818730) (← links)
- In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals. (Q52714849) (← links)
- AKR1C enzymes sustain therapy resistance in paediatric T-ALL. (Q53703893) (← links)
- The aldo-keto reductase superfamily and its role in drug metabolism and detoxification (Q56760512) (← links)
- Structural and Functional Biology of Aldo-Keto Reductase Steroid Transforming Enzymes (Q57111473) (← links)
- Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone (Q58577848) (← links)
- Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia (Q64055650) (← links)