Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia (Q64055650)

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scientific article published on 25 March 2019

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English	Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia	scientific article published on 25 March 2019

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scholarly article

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27 April 2020

Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia (English)

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27 April 2020

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inferred from title

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T-cell acute lymphoblastic leukemia

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based on heuristic

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acute myeloid leukemia

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1

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27 April 2020

Trevor M Penning

3

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27 April 2020

Paul C Trippier

4

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27 April 2020

author name string

Tianzhu Zang

2

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27 April 2020

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25 March 2019

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27 April 2020

Journal of Medicinal Chemistry

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27 April 2020

62

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27 April 2020

7

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27 April 2020

3590-3616

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27 April 2020

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural resistance of acute myeloid leukemia cell lines to mitoxantrone is associated with lack of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclopentenone prostaglandins: new insights on biological activities and cellular targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways activated by daunorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute promyelocytic leukemia: where does it stem from?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

En route to a motorized nanocar

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment decision-making for older patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: problems and approaches.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperating gene mutations in acute myeloid leukemia: a review of the literature.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging treatment strategies for acute myeloid leukemia (AML) in the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose daunorubicin in older patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daunorubicin versus mitoxantrone versus idarubicin as induction and consolidation chemotherapy for adults with acute myeloid leukemia: the EORTC and GIMEMA Groups Study AML-10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug combination studies and their synergy quantification using the Chou-Talalay method

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: bisphenylboronic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of T cell acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoid differentiation therapy for common types of acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKR1C3 as a target in castrate resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of adults with T-cell lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute lymphoblastic leukemia: a comprehensive review and 2017 update

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer statistics, 2018.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30836001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.JMEDCHEM.9B00090

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30836001%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30836001%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30836001%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

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