Pages that link to "Q28185671"
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The following pages link to A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex (Q28185671):
Displaying 50 items.
- Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL (Q24324019) (← links)
- Structural biology of presenilin 1 complexes (Q27023904) (← links)
- Complex regulation of γ-secretase: from obligatory to modulatory subunits (Q28080576) (← links)
- Assembly, trafficking and function of gamma-secretase (Q28268951) (← links)
- Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 (Q28277779) (← links)
- APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development (Q28592373) (← links)
- Tailoring of membrane proteins by alternative splicing of pre-mRNA. (Q30418167) (← links)
- GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. (Q33276402) (← links)
- Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease (Q33327152) (← links)
- ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer (Q33662919) (← links)
- An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease (Q33879010) (← links)
- What is the role of amyloid precursor protein dimerization? (Q33977500) (← links)
- Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. (Q33996381) (← links)
- Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase (Q34193760) (← links)
- Notch inhibitors for cancer treatment (Q34330869) (← links)
- Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease (Q34728911) (← links)
- Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy (Q35065205) (← links)
- Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex (Q35172682) (← links)
- Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. (Q35676850) (← links)
- Cerebrospinal fluid Aβ42 levels and APP processing pathway genes in Parkinson's disease (Q35772659) (← links)
- Presenilin function and gamma-secretase activity (Q36109130) (← links)
- The GxxxG motif in the transmembrane domain of AbetaPP plays an essential role in the interaction of CTF beta with the gamma-secretase complex and the formation of amyloid-beta (Q36248813) (← links)
- Sampling the conformational space of the catalytic subunit of human γ-secretase (Q36479662) (← links)
- The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase (Q36481878) (← links)
- The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid (Q36582358) (← links)
- A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? (Q36674481) (← links)
- A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates (Q36898612) (← links)
- Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease (Q37108151) (← links)
- Cerebral arachidonate cascade in dementia: Alzheimer's disease and vascular dementia (Q37211768) (← links)
- APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes (Q37269196) (← links)
- Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease. (Q37338808) (← links)
- BRI2 homodimerizes with the involvement of intermolecular disulfide bonds. (Q37440201) (← links)
- Gamma-secretase and the intramembrane proteolysis of Notch (Q37785197) (← links)
- Insights into the transmembrane helix associations of kit ligand by molecular dynamics simulation and TOXCAT. (Q38859454) (← links)
- Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease (Q39041998) (← links)
- Ubiquitin-proteasome pathway mediates degradation of APH-1. (Q40216642) (← links)
- Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif (Q40270809) (← links)
- Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. (Q40360520) (← links)
- Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. (Q40472890) (← links)
- A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. (Q40493609) (← links)
- Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins (Q40541170) (← links)
- Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs (Q41822677) (← links)
- Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice (Q42859672) (← links)
- Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and function. (Q42956952) (← links)
- Defining the minimum substrate and charge recognition model of gamma-secretase (Q45893376) (← links)
- Nicastrin functions as a gamma-secretase-substrate receptor (Q46646587) (← links)
- Allosteric Modulation of Intact γ-Secretase Structural Dynamics (Q47270654) (← links)
- The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels (Q50643833) (← links)
- Structural and Chemical Biology of Presenilin Complexes (Q51093204) (← links)
- Molecular models of the interface between anterior pharynx-defective protein 1 (APH-1) and presenilin involving GxxxG motifs. (Q53290901) (← links)