Sampling the conformational space of the catalytic subunit of human γ-secretase (Q36479662)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Sampling the conformational space of the catalytic subunit of human γ-secretase (English)

1 reference

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1 March 2020

1

1 reference

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1 March 2020

Eeson Rajendra

2

1 reference

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1 March 2020

Sjors Scheres

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Guanghui Yang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Yigong Shi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

language of work or name

English

0 references

publication date

1 December 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes

1 March 2020

cites work

1 reference

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An atomic structure of human γ-secretase

30 September 2017

1 reference

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The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

30 September 2017

1 reference

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Cryo-EM structure of SNAP-SNARE assembly in 20S particle.

30 September 2017

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How cryo-EM is revolutionizing structural biology

30 September 2017

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Trajectories of the ribosome as a Brownian nanomachine

30 September 2017

1 reference

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Three-dimensional structure of human γ-secretase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

30 September 2017

1 reference

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Structure of the Yeast Mitochondrial Large Ribosomal Subunit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators

30 September 2017

1 reference

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Structure of the SecY channel during initiation of protein translocation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

RELION: implementation of a Bayesian approach to cryo-EM structure determination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Prevention of overfitting in cryo-EM structure determination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Features and development of Coot

30 September 2017

1 reference

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Structural analysis of viral nucleocapsids by subtraction of partial projections

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

EMAN2: an extensible image processing suite for electron microscopy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Refinement of macromolecular structures by the maximum-likelihood method

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

30 September 2017

https://pubmed.ncbi.nlm.nih.gov/26623517

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bacteriophage phi29 scaffolding protein gp7 before and after prohead assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Probability-based protein identification by searching sequence databases using mass spectrometry data

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Semi-automated selection of cryo-EM particles in RELION-1.3.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Conformation-independent structural comparison of macromolecules with ProSMART

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Lessons from a failed γ-secretase Alzheimer trial

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Beam-induced motion correction for sub-megadalton cryo-EM particles.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Nicastrin functions as a gamma-secretase-substrate receptor

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

Designed Helical Peptides Inhibit an Intramembrane Protease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

21 September 2018

1 reference

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Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

21 September 2018

1 reference

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 September 2018

1 reference

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 September 2018

1 reference

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718806

4 December 2018

Identifiers

DOI

10.7554/ELIFE.11182

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

26623517

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26623517%20AND%20SRC:MED&resulttype=core&format=json