Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (Q14907300)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Mus musculus

APECED protein homolog
Aire
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
autoimmune regulator AIRE1a
autoimmune regulator

Language	Label	Description	Also known as
English	Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	mammalian protein found in Mus musculus	APECED protein homolog Aire autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog autoimmune regulator AIRE1a autoimmune regulator

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Zinc finger, FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

SAND-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

Autoimmune regulator, AIRE

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

Zinc finger, PHD-finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

HSR domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, PHD-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

SAND domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, PHD-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

histone binding

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

zinc ion binding

determination method or standard

chromatin binding

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

transcription coregulator activity

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

translation regulator activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

identical protein binding

determination method or standard

1 reference

14 February 2019

The autoimmune regulator (AIRE) is a DNA-binding protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Modulation of Aire regulates the expression of tissue-restricted antigens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

determination method or standard

4 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

27 March 2018

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

27 March 2018

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

determination method or standard

1 reference

14 February 2019

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

biological process

positive regulation of transcription, DNA-templated

determination method or standard

regulation of translation

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

4 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

27 March 2018

Modulation of Aire regulates the expression of tissue-restricted antigens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

27 March 2018

Modulation of Aire regulates the expression of tissue-restricted antigens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

negative thymic T cell selection

determination method or standard

1 reference

27 March 2018

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

peripheral T cell tolerance induction

determination method or standard

1 reference

27 March 2018

Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

central tolerance induction to self antigen

determination method or standard

3 references

chemokine production

determination method or standard

1 reference

27 March 2018

Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

thymus epithelium morphogenesis

determination method or standard

1 reference

27 March 2018

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

regulation of thymocyte migration

determination method or standard

1 reference

27 March 2018

Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0E3&geneProductId=UniProtKB:Q9Z0E3

determination method or standard

peripheral T cell tolerance induction

determination method or standard

central tolerance induction to self antigen

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

humoral immune response

determination method or standard

3 references

14 February 2019

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

chemokine production

determination method or standard

negative thymic T cell selection

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Modulation of Aire regulates the expression of tissue-restricted antigens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Modulation of Aire regulates the expression of tissue-restricted antigens

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0E3

determination method or standard

thymus epithelium morphogenesis

determination method or standard

regulation of thymocyte migration

determination method or standard

Zinc finger, PHD-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

Zinc finger, PHD-finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

Zinc finger, PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z0E3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000101034

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101034

ENSMUSP00000101035

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000101035

ENSMUSP00000114904

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000114904

ENSMUSP00000115162

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000115162

ENSMUSP00000118317

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000118317

ENSMUSP00000120150

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120150

ENSMUSP00000121477

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121477

ENSMUSP00000122190

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122190

ENSMUSP00000122659

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122659

ENSMUSP00000019257

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000019257

ENSMUSP00000117094

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000117094

ENSMUSP00000114808

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000114808

ENSMUSP00000123678

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000123678

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q14907300&oldid=2023071357"