Lamin A (Q14911833)

Intermediate filament, rod domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lamin tail domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

structural molecule activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

1 reference

10 September 2018

protein binding

4 references

10 September 2018

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Coupling of the nucleus and cytoplasm: role of the LINC complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Samp1 is a component of TAN lines and is required for nuclear movement

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Distinct changes in intranuclear lamin A/C organization during myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

identical protein binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

protein phosphatase 1 binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

cell component

nuclear lamina

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

1 reference

10 September 2018

nuclear envelope

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

7 references

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Ensembl genome database project

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

lamin filament

1 reference

10 September 2018

cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

nucleus

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

9 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Ensembl genome database project

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Distinct changes in intranuclear lamin A/C organization during myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

CDK4 is an essential insulin effector in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

4 references

10 September 2018

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

10 September 2018

Ensembl genome database project

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

nuclear membrane

1 reference

10 September 2018

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

nuclear matrix

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

regulation of cell migration

biological process

1 reference

10 September 2018

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

nucleus organization

1 reference

24 April 2018

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

establishment or maintenance of microtubule cytoskeleton polarity

1 reference

10 September 2018

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

negative regulation of release of cytochrome c from mitochondria

1 reference

10 September 2018

LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

negative regulation of extrinsic apoptotic signaling pathway

1 reference

10 September 2018

LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

regulation of protein localization to nucleus

1 reference

10 September 2018

Samp1 is a component of TAN lines and is required for nuclear movement

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

positive regulation of gene expression

1 reference

10 September 2018

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

establishment of cell polarity

NAS

1 reference

10 September 2018

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

protein localization to nucleus

NAS

ventricular cardiac muscle cell development

1 reference

10 September 2018

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

negative regulation of mesenchymal cell proliferation

1 reference

10 September 2018

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

regulation of telomere maintenance

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

negative regulation of cardiac muscle hypertrophy in response to stress

1 reference

10 September 2018

Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

protein import into nucleus

1 reference

10 September 2018

Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

positive regulation of osteoblast differentiation

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

negative regulation of adipose tissue development

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

nucleus organization

IGI

regulation of protein stability

1 reference

10 September 2018

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

positive regulation of histone H3-K9 trimethylation

1 reference

10 September 2018

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48678&geneProductId=UniProtKB:P48678

1 reference

Intermediate filament protein, conserved site

1 reference

Intermediate filament, rod domain

1 reference