8-oxoguanine DNA-glycosylase 1 (Q14912159)

8-oxoguanine DNA-glycosylase

1 reference

Helix-turn-helix, base-excision DNA repair, C-terminal

1 reference

8-oxoguanine DNA glycosylase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HhH-GPD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

oxidized base lesion DNA N-glycosylase activity

TAS

1 reference

14 February 2019

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

TAS

microtubule binding

1 reference

14 February 2019

The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

hydrolase activity, acting on glycosyl bonds

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

14 February 2019

damaged DNA binding

lyase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

14 February 2019

DNA-(apurinic or apyrimidinic site) endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

1 reference

27 February 2018

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

2 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

14 February 2019

oxidized purine nucleobase lesion DNA N-glycosylase activity

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

14 February 2019

class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

1 reference

27 February 2018

oxidized purine nucleobase lesion DNA N-glycosylase activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

DNA N-glycosylase activity

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

IBA

cell component

nuclear speck

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

nuclear matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

nucleus

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

mitochondrion

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

nucleus

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

IBA

mitochondrion

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

HDA

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

nucleotide-excision repair

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

14 February 2019

regulation of transcription, DNA-templated

ISS

response to light stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

cellular response to cadmium ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

response to oxidative stress

ISS

cellular response to DNA damage stimulus

The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

acute inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

response to radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

14 February 2019

response to folic acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

response to ethanol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

DNA repair

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

IMP

14 February 2019

Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

IMP

14 February 2019

Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

IMP

14 February 2019

Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

IGI

14 February 2019

A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

human ageing

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

negative regulation of apoptotic process

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

response to estradiol

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

base-excision repair

A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

27 February 2018

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08760&geneProductId=UniProtKB:O08760

base-excision repair

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

14 February 2019

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

base-excision repair, AP site formation

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08760

1 reference

8-oxoguanine DNA glycosylase, N-terminal

1 reference