The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity (Q24297634)

protein autophosphorylation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Thomas Meitinger

6

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Holger Prokisch

8

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Marius Ueffing

Christian Johannes Gloeckner

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1

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Ralf J. Braun

object named as

Ralf J Braun

4

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Walter Kolch

object named as

Walter Kolch

7

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Norbert Kinkl

2

object named as

Norbert Kinkl

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author name string

Annette Schumacher

3

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Eric O'Neill

Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250.

5

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language of work or name

English

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publication date

15 January 2006

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published in

Human Molecular Genetics

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volume

15

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issue

2

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page(s)

223-32

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cites work

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Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

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Regulation of protein kinases; controlling activity through activation segment conformation

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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The RIP kinases: crucial integrators of cellular stress

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A common LRRK2 mutation in idiopathic Parkinson's disease

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LRRK2 mutations and Parkinsonism

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LRRK2 mutations and Parkinsonism

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The leucine-rich repeat as a protein recognition motif

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Regulation and targets of receptor tyrosine kinases

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The WD repeat: a common architecture for diverse functions

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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Functional organization of the yeast proteome by systematic analysis of protein complexes

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Switching on kinases: oncogenic activation of BRAF and the PDGFR family

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DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer

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DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation

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DJ-1 has a role in antioxidative stress to prevent cell death

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

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Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease

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Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

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The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation

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Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling

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Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

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Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

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The protein kinase complement of the human genome

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons

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Mechanism of inhibition of Raf-1 by protein kinase A.

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Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

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The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

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LRRK2 mutations in Parkinson disease

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A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

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Identifiers

DOI

10.1093/HMG/DDI439

1 reference

Consolidated OpenCitations Corpus – April 2017

release_n353s577tbavjjrptmpl5n2thu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/n353s577tbavjjrptmpl5n2thu

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16321986

1 reference

Consolidated OpenCitations Corpus – April 2017