TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation (Q24291517)

Fas (TNF receptor superfamily member 6)

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Harvey Lodish

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Robert Weinberg

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author name string

R Perlman

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W P Schiemann

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M W Brooks

The transforming growth factor-beta family

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language of work or name

English

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publication date

August 2001

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published in

Nature Cell Biology

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volume

3

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issue

8

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page(s)

708-14

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cites work

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7 January 2021

TGF-beta: a critical modulator of immune cell function

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

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Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc.

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TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha

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Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions

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Programmed cell death in animal development

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A matter of life and cell death

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Die and let live: eliminating dangerous lymphocytes

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Apoptosis by death factor

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Smads: transcriptional activators of TGF-beta responses

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Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway

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G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation

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Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

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7 January 2021

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

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7 January 2021

Dissecting Fas signaling with an altered-specificity death-domain mutant: requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation

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Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

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7 January 2021

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

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7 January 2021

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

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Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

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Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development

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Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases

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Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha

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Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis

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Genetic evidence that formins function within the nucleus

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Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

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Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

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Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction

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The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response

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Production of high-titer helper-free retroviruses by transient transfection

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Signal transduction by receptors with tyrosine kinase activity

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Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12

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A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor

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Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

1 reference

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

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Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells.

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Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1 reference

7 January 2021