Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome (Q24291893)

GOA release 2020-03-11

face morphogenesis

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GOA release 2020-03-11

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M Tartaglia

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author name string

E L Mehler

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R Goldberg

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G Zampino

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H G Brunner

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H Kremer

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I van der Burgt

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A H Crosby

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A Ion

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S Jeffery

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K Kalidas

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M A Patton

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R S Kucherlapati

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B D Gelb

Hypertelorism With Turner Phenotype

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language of work or name

English

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publication date

December 2001

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published in

Nature Genetics

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volume

29

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issue

4

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page(s)

465-8

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cites work

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7 January 2021

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7 January 2021

Mapping a gene for Noonan syndrome to the long arm of chromosome 12

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7 January 2021

Fine mapping of Noonan/cardio-facio cutaneous syndrome in a large family

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Genetic heterogeneity in Noonan syndrome: evidence for an autosomal recessive form

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Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3.

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7 January 2021

Shp-2 tyrosine phosphatase: signaling one cell or many

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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

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Crystal structure of the tyrosine phosphatase SHP-2

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7 January 2021

Efficient Monte Carlo method for simulation of fluctuating conformations of native proteins.

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7 January 2021

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

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Insulin signaling in mice expressing reduced levels of Syp.

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

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The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

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7 January 2021

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

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Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

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7 January 2021

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

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7 January 2021

SHP-2, SH2-containing protein tyrosine phosphatase-2.

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7 January 2021

Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.

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7 January 2021

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

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7 January 2021

Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

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7 January 2021

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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7 January 2021

Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor

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7 January 2021

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

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7 January 2021

All-atom empirical potential for molecular modeling and dynamics studies of proteins

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7 January 2021