Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells (Q24304986)

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16 January 2020

title

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells (English)

1 reference

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positive regulation of interleukin-17 production

16 January 2020

main subject

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1905078

regulation of interleukin-17 production

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1905076

negative regulation of interleukin-17 production

1 reference

Gene Ontology release 2020-05-02

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Interleukin 12B

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Interleukin 2

1 reference

Interleukin 18

1 reference

Interleukin 12A

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Interleukin 23 subunit alpha

1 reference

Interleukin 21

1 reference

positive regulation of inflammatory response

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author

René de Waal Malefyt

5

1 reference

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16 January 2020

6

Tom H M Ottenhoff

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Marieke A Hoeve

1

1 reference

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16 January 2020

Nigel D L Savage

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Tjitske de Boer

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Dennis M L Langenberg

4

1 reference

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16 January 2020

Frank A W Verreck

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

English

0 references

publication date

1 March 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482511%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Immunology

16 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16482511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

36

1 reference

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16 January 2020

issue

3

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16 January 2020

page(s)

661-670

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

16 January 2020

cites work

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Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

21 January 2018

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Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis

21 January 2018

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IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.

21 January 2018

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Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency

21 January 2018

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Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae

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7 January 2021

Interleukin-12 and the regulation of innate resistance and adaptive immunity

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7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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7 January 2021

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria

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7 January 2021

IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency

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7 January 2021

The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses

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7 January 2021

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

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7 January 2021

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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7 January 2021

IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination

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7 January 2021

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

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7 January 2021

Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system

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7 January 2021

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

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7 January 2021

Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy

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7 January 2021

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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7 January 2021

Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway

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7 January 2021

Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes

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7 January 2021

High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism

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7 January 2021

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

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7 January 2021

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

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7 January 2021

Increased interleukin-17 production in patients with systemic sclerosis

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7 January 2021

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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7 January 2021

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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7 January 2021

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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7 January 2021

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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7 January 2021

T(H)-17: a giant step from T(H)1 and T(H)2

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7 January 2021

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

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7 January 2021

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

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7 January 2021