Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases (Q24306594)

GOA release 2020-03-11

protein phosphorylation

1 reference

PTK2 protein tyrosine kinase 2

GOA release 2020-03-11

1 reference

Molecular and Cellular Biology

GOA release 2020-03-11

author name string

M B Calalb

series ordinal

1

0 references

T R Polte

series ordinal

2

0 references

S K Hanks

series ordinal

3

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language of work or name

English

0 references

publication date

February 1995

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published in

0 references

volume

15

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issue

2

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page(s)

954-63

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cites work

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Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

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Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

19 March 2017

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Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

19 March 2017

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The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation

19 March 2017

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Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)

19 March 2017

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19 March 2017

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

19 March 2017

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19 March 2017

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Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton

19 March 2017

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19 March 2017

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Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

6 April 2017

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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Crystal structure of cyclin-dependent kinase 2

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The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues

27 September 2017

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Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

27 September 2017

1 reference

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Protein kinase regulation: insights from crystal structure analysis

27 September 2017

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Paxillin: a cytoskeletal target for tyrosine kinases

27 September 2017

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Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

27 September 2017

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Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

27 September 2017

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Protein modification: phosphorylation on tyrosine residues

27 September 2017

1 reference

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Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation

27 September 2017

1 reference

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Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells

27 September 2017

1 reference

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Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

27 September 2017

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Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein

27 September 2017

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Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins

27 September 2017

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Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

27 September 2017

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Cytoskeleton--plasma membrane interactions

27 September 2017

1 reference

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Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets

27 September 2017

1 reference

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Transformation of mammalian cells with genes from procaryotes and eucaryotes

27 September 2017

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Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor

27 September 2017

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Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

27 September 2017

1 reference

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Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

Signaling by integrins: implications for tumorigenesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

Chicken and mouse focal adhesion kinases are similar in structure at their amino termini

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231984

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7529876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/7529876